Nora. Pällmann, et.al., Biological Relevance and Therapeutic Potential of the Hypusine Modification System., The Journal of biological chemistry, 2015, 290

http://rdf.ncbi.nlm.nih.gov/pubmed/26037925

Nora. Pällmann, et.al., Biological Relevance and Therapeutic Potential of the Hypusine Modification System., The Journal of biological chemistry, 2015, 290

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Eif5a2<tm1d(EUCOMM)Hmgu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812102
• Dhps<tm2d(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812111
• Dhps<tm2c(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812110
• Eif5a2<tm1c(EUCOMM)Hmgu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812101

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• cachexia_Dohh<tm1.1Sbal>/Dohh<tm1.1Sbal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0005150I129S1Sv129X1SvJBALBcJDohhtm11SbalDohhtm11SbalTgCAGcreEsr15Amc0Dohhtm11SbalTgCAGcreEsr15Amc
• increased kidney iron level_Dhps<tm2c(EUCOMM)Wtsi>/Dhps<tm2c(EUCOMM)Wtsi>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010375IC57BL6JC57BL6NCBASJLDhpstm2cEUCOMMWtsiDhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc0Dhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc
• premature death_Dhps<tm2c(EUCOMM)Wtsi>/Dhps<tm2c(EUCOMM)Wtsi>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0002083IC57BL6JC57BL6NCBASJLDhpstm2cEUCOMMWtsiDhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc0Dhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc
• focal hepatic necrosis_Dohh<tm1.1Sbal>/Dohh<tm1.1Sbal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001656I129S1Sv129X1SvJBALBcJDohhtm11SbalDohhtm11SbalTgCAGcreEsr15Amc0Dohhtm11SbalTgCAGcreEsr15Amc
• premature death_Dohh<tm1.1Sbal>/Dohh<tm1.1Sbal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJBALBcJDohhtm11SbalDohhtm11SbalTgCAGcreEsr15Amc0Dohhtm11SbalTgCAGcreEsr15Amc
• no abnormal phenotype detected_Eif5a2<tm1d(EUCOMM)Hmgu>/Eif5a2<tm1d(EUCOMM)Hmgu>
  http://metadb.riken.jp/0002169IBALBcJC57BL6JC57BL6NSJLEif5a2tm1dEUCOMMHmguEif5a2tm1dEUCOMMHmguEif5a2tm1dEUCOMMHmgu
• decreased body weight_Dhps<tm2c(EUCOMM)Wtsi>/Dhps<tm2c(EUCOMM)Wtsi>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001262IC57BL6JC57BL6NCBASJLDhpstm2cEUCOMMWtsiDhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc0Dhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc
• prenatal lethality, complete penetrance_Dhps<tm2d(EUCOMM)Wtsi>/Dhps<tm2d(EUCOMM)Wtsi>
  http://metadb.riken.jp/0011091IBALBcJC57BL6JC57BL6NSJLDhpstm2dEUCOMMWtsiDhpstm2dEUCOMMWtsiDhpstm2dEUCOMMWtsi
• hepatic necrosis_Dohh<tm1.1Sbal>/Dohh<tm1.1Sbal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001654I129S1Sv129X1SvJBALBcJDohhtm11SbalDohhtm11SbalTgCAGcreEsr15Amc0Dohhtm11SbalTgCAGcreEsr15Amc
• decreased body weight_Dohh<tm1.1Sbal>/Dohh<tm1.1Sbal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJBALBcJDohhtm11SbalDohhtm11SbalTgCAGcreEsr15Amc0Dohhtm11SbalTgCAGcreEsr15Amc
• increased kidney iron level_Dohh<tm1.1Sbal>/Dohh<tm1.1Sbal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010375I129S1Sv129X1SvJBALBcJDohhtm11SbalDohhtm11SbalTgCAGcreEsr15Amc0Dohhtm11SbalTgCAGcreEsr15Amc
• decreased bone marrow cell number_Dhps<tm2c(EUCOMM)Wtsi>/Dhps<tm2c(EUCOMM)Wtsi>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0000333IC57BL6JC57BL6NCBASJLDhpstm2cEUCOMMWtsiDhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc0Dhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc
• decreased spleen red pulp amount_Dhps<tm2c(EUCOMM)Wtsi>/Dhps<tm2c(EUCOMM)Wtsi>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0008477IC57BL6JC57BL6NCBASJLDhpstm2cEUCOMMWtsiDhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc0Dhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc
• cachexia_Dhps<tm2c(EUCOMM)Wtsi>/Dhps<tm2c(EUCOMM)Wtsi>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0005150IC57BL6JC57BL6NCBASJLDhpstm2cEUCOMMWtsiDhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc0Dhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc
• spleen hypoplasia_Dhps<tm2c(EUCOMM)Wtsi>/Dhps<tm2c(EUCOMM)Wtsi>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0000694IC57BL6JC57BL6NCBASJLDhpstm2cEUCOMMWtsiDhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc0Dhpstm2cEUCOMMWtsiTgCAGcreEsr15Amc
• renal tubular necrosis_Dohh<tm1.1Sbal>/Dohh<tm1.1Sbal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0004154I129S1Sv129X1SvJBALBcJDohhtm11SbalDohhtm11SbalTgCAGcreEsr15Amc0Dohhtm11SbalTgCAGcreEsr15Amc

class

http://purl.org/net/cito/citesAsAuthority

• Eif5a2<tm1d(EUCOMM)Hmgu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812102
• Dhps<tm2d(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812111
• Dhps<tm2c(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812110
• Eif5a2<tm1c(EUCOMM)Hmgu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5812101