Qian. Chen, et.al., Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP., Genes & development, 2015, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/26109051

Qian. Chen, et.al., Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP., Genes & development, 2015, 29

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lats2<tm1.1Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5648494
• Yap1<tm2.1Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5660284

class

http://purl.org/net/cito/citesAsAuthority

• Lats2<tm1.1Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5648494
• Yap1<tm2.1Dupa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5660284

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal bile duct epithelium morphology_Nf2<tm2Gth>/Nf2<tm2Gth>,Yap1<tm2.1Dupa>/Yap1<tm2.1Dupa>
  http://metadb.riken.jp/0013611I129P2OlaHsdNf2tm2GthNf2tm2GthYap1tm21DupaYap1tm21DupaYap1tm21DupaNf2tm2Gth
• abnormal bile duct epithelium morphology_Nf2<tm2Gth>/Nf2<tm2Gth>
  http://metadb.riken.jp/0013611I129P2OlaHsdNf2tm2GthNf2tm2GthNf2tm2Gth
• abnormal bile duct epithelium morphology_Lats1<tm1Noj>/Lats1<tm1Noj>,Lats2<tm1.1Dupa>/Lats2<tm1.1Dupa>,Wwtr1<tm1.2Eno>/Wwtr1<tm1.2Eno>,Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>
  http://metadb.riken.jp/0013611I129P2OlaHsd129SSvEv129S2SvPasLats1tm1NojLats1tm1NojLats2tm11DupaLats2tm11DupaWwtr1tm12EnoWwtr1tm12EnoYap1tm11DupaYap1tm11DupaLats1tm1NojWwtr1tm12EnoYap1tm11DupaLats2tm11Dupa
• enlarged liver_Lats1<tm1Noj>/Lats1<tm1Noj>,Lats2<tm1.1Dupa>/Lats2<tm1.1Dupa>
  http://metadb.riken.jp/0000599I129P2OlaHsd129S2SvPasLats1tm1NojLats1tm1NojLats2tm11DupaLats2tm11DupaLats2tm11DupaLats1tm1Noj
• abnormal bile duct epithelium morphology_Lats1<tm1Noj>/Lats1<tm1Noj>,Lats2<tm1.1Dupa>/Lats2<tm1.1Dupa>
  http://metadb.riken.jp/0013611I129P2OlaHsd129S2SvPasLats1tm1NojLats1tm1NojLats2tm11DupaLats2tm11DupaLats2tm11DupaLats1tm1Noj
• increased hamartoma incidence_Nf2<tm2Gth>/Nf2<tm2Gth>,Yap1<tm2.1Dupa>/Yap1<tm2.1Dupa>
  http://metadb.riken.jp/0010306I129P2OlaHsdNf2tm2GthNf2tm2GthYap1tm21DupaYap1tm21DupaYap1tm21DupaNf2tm2Gth
• increased liver weight_Lats1<tm1Noj>/Lats1<tm1Noj>,Lats2<tm1.1Dupa>/Lats2<tm1.1Dupa>
  http://metadb.riken.jp/0002981I129P2OlaHsd129S2SvPasLats1tm1NojLats1tm1NojLats2tm11DupaLats2tm11DupaLats2tm11DupaLats1tm1Noj
• enlarged liver_Lats1<tm1Noj>/Lats1<tm1Noj>,Lats2<tm1.1Dupa>/Lats2<tm1.1Dupa>,Wwtr1<tm1.2Eno>/Wwtr1<tm1.2Eno>,Yap1<tm1.1Dupa>/Yap1<tm1.1Dupa>
  http://metadb.riken.jp/0000599I129P2OlaHsd129SSvEv129S2SvPasLats1tm1NojLats1tm1NojLats2tm11DupaLats2tm11DupaWwtr1tm12EnoWwtr1tm12EnoYap1tm11DupaYap1tm11DupaLats1tm1NojWwtr1tm12EnoYap1tm11DupaLats2tm11Dupa
• abnormal bile duct physiology_Nf2<tm2Gth>/Nf2<tm2Gth>,Yap1<tm2.1Dupa>/Yap1<tm2.1Dupa>
  http://metadb.riken.jp/0003252I129P2OlaHsdNf2tm2GthNf2tm2GthYap1tm21DupaYap1tm21DupaYap1tm21DupaNf2tm2Gth
• no abnormal phenotype detected_Lats2<tm1.1Dupa>/Lats2<tm1.1Dupa>
  http://metadb.riken.jp/0002169I129P2OlaHsdLats2tm11DupaLats2tm11DupaLats2tm11Dupa
• increased incidence of tumors by chemical induction_Yap1<tm2.1Dupa>/Yap1<tm2.1Dupa>
  http://metadb.riken.jp/0004499NSYap1tm21DupaYap1tm21DupaYap1tm21Dupa
• enlarged liver_Nf2<tm2Gth>/Nf2<tm2Gth>,Yap1<tm2.1Dupa>/Yap1<tm2.1Dupa>
  http://metadb.riken.jp/0000599I129P2OlaHsdNf2tm2GthNf2tm2GthYap1tm21DupaYap1tm21DupaYap1tm21DupaNf2tm2Gth

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal bile duct epithelium morphology in RBRC02344
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015202