Hans D. Brightbill, et.al., Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation., Journal of immunology (Baltimore, Md. : 1950), 2015, 195

http://rdf.ncbi.nlm.nih.gov/pubmed/26116508

Hans D. Brightbill, et.al., Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation., Journal of immunology (Baltimore, Md. : 1950), 2015, 195

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Map3k14<tm1.1Gne>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5903065
• Map3k14<tm1.2Gne>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5903085

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased Peyer's patch number_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0008133B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor
• decreased transitional stage T1 B cell number_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0009923B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• abnormal thymus cell ratio_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0008827B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• small brachial lymph nodes_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0009629B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• small axillary lymph nodes_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0009632B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• absent Peyer's patches_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0002831B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• abnormal spleen marginal zone morphology_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0002362B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• absent popliteal lymph nodes_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0009634B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased IgA level_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0001807B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased germinal center B cell number_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0008178B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor
• decreased IgA level_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0001807B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor
• abnormal B cell physiology_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0002459B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased B cell number_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0005017B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased follicular B cell number_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0008174B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased marginal zone B cell number_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0008182B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• absent inguinal lymph nodes_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0009622B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased IgG1 level_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0008495B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor
• decreased B-2 B cell number_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0008207B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• abnormal immunoglobulin level_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0002490B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor
• decreased transitional stage T2 B cell number_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0009926B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased B cell proliferation_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0005093B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor
• decreased IgM level_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0001806B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor
• decreased germinal center B cell number_Map3k14<tm1.2Gne>/Map3k14<tm1.2Gne>
  http://metadb.riken.jp/0008178B6CgMap3k14tm12GneMap3k14tm12GneMap3k14tm12GneMap3k14tm12Gne
• decreased B cell number_Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>,Map3k14<tm1.1Gne>/Map3k14<tm1.1Gne>
  http://metadb.riken.jp/0005017B6CgMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sortm9creESR1ArteGtROSA26SorMap3k14tm11GneMap3k14tm11GneMap3k14tm11GneGtROSA26Sortm9creESR1ArteGtROSA26Sor

class

http://purl.org/net/cito/citesAsAuthority

• Map3k14<tm1.1Gne>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5903065
• Map3k14<tm1.2Gne>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5903085