Adam K. Walker, et.al., Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43., Acta neuropathologica, 2015, 130

http://rdf.ncbi.nlm.nih.gov/pubmed/26197969

Adam K. Walker, et.al., Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43., Acta neuropathologica, 2015, 130

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(NEFH-tTA)8Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:5693898

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased motor neuron number_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0000939IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• tremors_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0000745IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• neuronal cytoplasmic inclusions_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0011975IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• decreased skeletal muscle mass_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0004819IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• brain atrophy_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0012506IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• astrocytosis_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0003354IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• abnormal neuromuscular synapse morphology_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0001053IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• thin cerebral cortex_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0006254IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• neurodegeneration_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0002229IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• premature death_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0002083IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• impaired coordination_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0001405IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• decreased grip strength_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0010053IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• abnormal neuron morphology_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0002882IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• limb grasping_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0001513IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• abnormal innervation pattern to muscle_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0001052IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• impaired balance_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0001525IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• decreased brain size_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0000774IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle
• neuronal intranuclear inclusions_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP)12Vle/0
  http://metadb.riken.jp/0004191IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP12Vle0TgtetOTARDBP12VleTgNEFHtTA8Vle
• weight loss_Tg(NEFH-tTA)8Vle/0,Tg(tetO-TARDBP*)4Vle/0
  http://metadb.riken.jp/0001263IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOTARDBP4Vle0TgNEFHtTA8VleTgtetOTARDBP4Vle

class

http://purl.org/net/cito/citesAsAuthority

• Tg(NEFH-tTA)8Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:5693898