Olivier. Boucherat, et.al., Epithelial inactivation of Yy1 abrogates lung branching morphogenesis., Development (Cambridge, England), 2015, 142

http://rdf.ncbi.nlm.nih.gov/pubmed/26329601

Olivier. Boucherat, et.al., Epithelial inactivation of Yy1 abrogates lung branching morphogenesis., Development (Cambridge, England), 2015, 142

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal respiratory epithelium physiology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0014200I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal airway basal cell morphology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0011113I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• respiratory failure_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0001953I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• decreased respiratory mucosa goblet cell number_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0010862I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• increased lung apoptosis_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0030002I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal trachea morphology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0002282I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal tracheal cartilage morphology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0003120I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal lung morphology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0001175I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• impaired myofibroblast differentiation_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0012197I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• lung cysts_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0004880I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• trachea stenosis_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0010883I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• neonatal lethality, incomplete penetrance_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0011088I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiTgNkx21cre2Sand0TgNkx21cre2SandYy1tm21Yshi
• abnormal respiratory epithelium physiology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0014200I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiTgNkx21cre2Sand0TgNkx21cre2SandYy1tm21Yshi
• abnormal lung epithelium morphology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0006382I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal lung development_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0001176I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal lung-associated mesenchyme development_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0011142I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• increased blastoma incidence_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0008021I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiTgNkx21cre2Sand0TgNkx21cre2SandYy1tm21Yshi
• neonatal lethality, complete penetrance_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0011087I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal tracheal ciliated epithelium morphology_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0002285I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• abnormal branching involved in lung morphogenesis_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0011024I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• lung cysts_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0004880I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiTgNkx21cre2Sand0TgNkx21cre2SandYy1tm21Yshi
• decreased Clara cell number_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0010949I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• left pulmonary isomerism_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Shh<tm1(EGFP/cre)Cjt>/Shh<+>
  http://metadb.riken.jp/0003178I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiShhtm1EGFPcreCjtShhShhtm1EGFPcreCjtYy1tm21YshiShh
• lethality at weaning, complete penetrance_Yy1<tm2.1Yshi>/Yy1<tm2.1Yshi>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0011083I129S4SvJaeC57BL6Yy1tm21YshiYy1tm21YshiTgNkx21cre2Sand0TgNkx21cre2SandYy1tm21Yshi