Jessica M Y. Ng, et.al., Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53., Cancer research, 2015, 75

http://rdf.ncbi.nlm.nih.gov/pubmed/26363008

Jessica M Y. Ng, et.al., Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53., Cancer research, 2015, 75

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal brain white matter morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0008026I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• thin cerebral cortex_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0006254I129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2Sho
• gliosis_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0002183I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• ataxia_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001393I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• seizures_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0002064I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal cerebellum morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000849I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal gait_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001406I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• excessive scratching_Smarcb1<tm2Sho>/Smarcb1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001412I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1Trp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmTrp53tm1BrnSmarcb1Smarcb1tm2Sho
• abnormal limb posture_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0004263I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• demyelination_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000921I129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2Sho
• increased brain tumor incidence_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0009277I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal corpus callosum morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000780I129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2Sho
• decreased litter size_Smarcb1<tm2Sho>/Smarcb1<+>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001935I129S1SvC57BL6SJLSmarcb1tm2ShoSmarcb1TgNescre1Kln0Smarcb1TgNescre1KlnSmarcb1tm2Sho
• impaired coordination_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001405I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal cerebellar Purkinje cell layer_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000875I129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2Sho
• prenatal lethality, incomplete penetrance_Smarcb1<tm2Sho>/Smarcb1<+>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011101I129S1SvC57BL6SJLSmarcb1tm2ShoSmarcb1TgNescre1Kln0Smarcb1TgNescre1KlnSmarcb1tm2Sho
• abnormal corpus callosum morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000780I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal cerebral cortex morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000788I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• decreased body weight_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001262I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• prenatal lethality, complete penetrance_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011091I129S1SvC57BL6SJLSmarcb1tm2ShoSmarcb1tm2ShoTgNescre1Kln0TgNescre1KlnSmarcb1tm2Sho
• dystonia_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0005323I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• excessive scratching_Smarcb1<tm2Sho>/Smarcb1<+>,Trp53<tm1Brn>/Trp53<+>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001412I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1Trp53tm1BrnTrp53TgGFAPcreGtm0Smarcb1tm2ShoSmarcb1Trp53tm1BrnTgGFAPcreGtmTrp53
• abnormal cerebellum external granule cell layer morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000872I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• excessive scratching_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001412I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• decreased body size_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001265I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal cerebellar layer morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0009956I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal stride length_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0012690I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal cerebellar granule cell migration_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0009977I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal hippocampus morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000807I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal cerebellar granule cell migration_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0009977I129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2Sho
• abnormal locomotor behavior_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001392I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal brain white matter morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<+>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0008026I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53TgGFAPcreGtm0TgGFAPcreGtmTrp53Smarcb1tm2ShoTrp53tm1Brn
• decreased oligodendrocyte number_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0009808I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• axon degeneration_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0005405I129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2Sho
• lethargy_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0005202I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• abnormal brain white matter morphology_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0008026I129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2Sho
• circling_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0001394I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• tremors_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000745I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• decreased survivor rate_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0008770I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn
• hindlimb paralysis_Smarcb1<tm2Sho>/Smarcb1<tm2Sho>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(GFAP-cre)#Gtm/0
  http://metadb.riken.jp/0000755I129P2OlaHsd129S1SvC57BL6CBASmarcb1tm2ShoSmarcb1tm2ShoTrp53tm1BrnTrp53tm1BrnTgGFAPcreGtm0TgGFAPcreGtmSmarcb1tm2ShoTrp53tm1Brn