Vivian. Anastasiou, et.al., Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice., Diabetologia, 2016, 59

http://rdf.ncbi.nlm.nih.gov/pubmed/26518685

Vivian. Anastasiou, et.al., Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice., Diabetologia, 2016, 59

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792875

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired glucose tolerance_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0005293IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• abnormal pancreas development_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0003934IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased insulin secretion_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0003058IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• decreased insulin secretion_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0003059IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased pancreatic islet cell apoptosis_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0014121IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased pancreatic beta cell proliferation_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0011819IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased pancreatic beta cell apoptosis_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0014117IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased pancreatic alpha cell number_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0009176IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• abnormal pancreatic islet morphology_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0005215IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased pancreatic delta cell number_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0009180IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• hyperglycemia_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0001559IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• oxidative stress_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0003674IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• pancreatic islet hyperplasia_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0005491IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased pancreatic beta cell mass_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0009113IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• abnormal pancreatic beta cell differentiation_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0009175IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• insulin resistance_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0005331IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• increased glucagon secretion_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0002710IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg
• abnormal calcium ion homeostasis_Aldh1b1<tm1.1(KOMP)Vlcg>/Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0004231IC57BL6JC57BL6NTacCBAAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcgAldh1b1tm11KOMPVlcg

class

http://purl.org/net/cito/citesAsAuthority

• Aldh1b1<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792875