Kenichiro. Matsuzaki, et.al., FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway., Genes & development, 2015, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/26637282

Kenichiro. Matsuzaki, et.al., FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway., Genes & development, 2015, 29

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal seminiferous tubule morphology_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002216I129P2OlaHsd129S4SvJaeBrip1GtRRI409BygBrip1GtRRI409BygFancd2tm1HouFancd2tm1HouBrip1GtRRI409BygFancd2tm1Hou
• increased cellular sensitivity to DNA damaging agents_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0014040I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal double-strand DNA break repair_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0010948I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal cell physiology_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0005621I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• decreased litter size_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0001935I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• ovary cysts_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0002016I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal seminiferous tubule morphology_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0002216I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• induced chromosome breakage_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0004030I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• hepatic steatosis_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0002628I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal primary ovarian follicle morphology_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0009362I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• early cellular replicative senescence_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0008008I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• increased tumor incidence_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0002020I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• Sertoli cell hyperplasia_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0002776I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal chromosome morphology_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0003702I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• increased cellular sensitivity to DNA damaging agents_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0014040I129P2OlaHsd129S4SvJaeBrip1GtRRI409BygBrip1GtRRI409BygFancd2tm1HouFancd2tm1HouBrip1GtRRI409BygFancd2tm1Hou
• testicular atrophy_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0003205I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• reduced fertility_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0001921I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal DNA replication_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0008057I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• small testis_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001147I129P2OlaHsd129S4SvJaeBrip1GtRRI409BygBrip1GtRRI409BygFancd2tm1HouFancd2tm1HouBrip1GtRRI409BygFancd2tm1Hou
• decreased testis weight_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0004852I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• small testis_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0001147I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal spermatogonia morphology_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0006378I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• increased Harderian gland adenoma incidence_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0013538I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• endometrium hyperplasia_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0009092I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• chromosomal instability_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0008866I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• increased lymphoma incidence_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0012431I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• increased pituitary adenoma incidence_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0002041I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• abnormal ovary development_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0003582I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• increased adenocarcinoma incidence_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0009308I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg
• increased adenoma incidence_Brip1<Gt(RRI409)Byg>/Brip1<Gt(RRI409)Byg>
  http://metadb.riken.jp/0010383I129P2OlaHsdBrip1GtRRI409BygBrip1GtRRI409BygBrip1GtRRI409Byg