Yan. Chen, et.al., RANKL blockade prevents and treats aggressive osteosarcomas., Science translational medicine, 2015, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/26659571

Yan. Chen, et.al., RANKL blockade prevents and treats aggressive osteosarcomas., Science translational medicine, 2015, 7

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0002083I129129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0TgCol1a1cre1KryTrp53tm1BrnPrkar1atm12LskRb1tm2BrnPrkar1a
• increased osteosarcoma incidence_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003789I129129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aRb1tm2BrnRb1TgCol1a1cre1Kry0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1KryPrkar1aRb1tm2BrnPrkar1atm12LskRb1
• increased osteosarcoma incidence_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0003789I129129P2OlaHsdFVBNRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0Rb1tm2BrnTgCol1a1cre1KryTrp53tm1Brn
• increased osteosarcoma incidence_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0003789I129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aTgCol1a1cre1Kry0Trp53tm1BrnTrp53tm1BrnTgCol1a1cre1KryTrp53tm1BrnPrkar1atm12LskPrkar1a
• premature death_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aTgCol1a1cre1Kry0Trp53tm1BrnTrp53tm1BrnTgCol1a1cre1KryTrp53tm1BrnPrkar1atm12LskPrkar1a
• premature death_Tg(Bglap2-TAg)1Rkho/0
  http://metadb.riken.jp/0002083IFVBNTgBglap2TAg1Rkho0TgBglap2TAg1Rkho
• increased osteosarcoma incidence_Tg(Bglap2-TAg)1Rkho/0,Tnfsf11<tm1Pngr>/Tnfsf11<+>
  http://metadb.riken.jp/0003789I129P2OlaHsdFVBNTgBglap2TAg1Rkho0Tnfsf11tm1PngrTnfsf11Tnfsf11TgBglap2TAg1RkhoTnfsf11tm1Pngr
• increased osteosarcoma incidence_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0003789I129129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0TgCol1a1cre1KryTrp53tm1BrnPrkar1atm12LskRb1tm2BrnPrkar1a
• decreased skeletal tumor incidence_Tg(Bglap2-TAg)1Rkho/0,Tnfsf11<tm1Pngr>/Tnfsf11<tm1Pngr>
  http://metadb.riken.jp/0012426I129P2OlaHsdFVBNTgBglap2TAg1Rkho0Tnfsf11tm1PngrTnfsf11tm1PngrTgBglap2TAg1RkhoTnfsf11tm1Pngr
• increased osteosarcoma incidence_Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0,Tnfrsf11a<tm1.1Pngr>/Tnfrsf11a<tm1.1Pngr>
  http://metadb.riken.jp/0003789I129P2OlaHsdC57BL6FVBNTgBglap2TAg1Rkho0TgCol1a1cre1Kry0Tnfrsf11atm11PngrTnfrsf11atm11PngrTgCol1a1cre1KryTgBglap2TAg1RkhoTnfrsf11atm11Pngr
• premature death_Rb1<tm2Brn>/Rb1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0002083I129129P2OlaHsdFVBNRb1tm2BrnRb1Trp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0TgCol1a1cre1KryTrp53tm1BrnRb1Rb1tm2Brn
• increased osteosarcoma incidence_Rb1<tm2Brn>/Rb1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0003789I129129P2OlaHsdFVBNRb1tm2BrnRb1Trp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0TgCol1a1cre1KryTrp53tm1BrnRb1Rb1tm2Brn
• abnormal femur morphology_Tg(Bglap2-TAg)1Rkho/0,Tnfsf11<tm1Pngr>/Tnfsf11<tm1Pngr>
  http://metadb.riken.jp/0000559I129P2OlaHsdFVBNTgBglap2TAg1Rkho0Tnfsf11tm1PngrTnfsf11tm1PngrTgBglap2TAg1RkhoTnfsf11tm1Pngr
• increased osteosarcoma incidence_Tg(Bglap2-TAg)1Rkho/0
  http://metadb.riken.jp/0003789IFVBNTgBglap2TAg1Rkho0TgBglap2TAg1Rkho
• premature death_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aRb1tm2BrnRb1TgCol1a1cre1Kry0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1KryPrkar1aRb1tm2BrnPrkar1atm12LskRb1
• increased cell migration_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<+>,Tg(Col1a1-cre)1Kry/0,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0011804I129129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aRb1tm2BrnRb1TgCol1a1cre1Kry0Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1KryPrkar1aRb1tm2BrnPrkar1atm12LskRb1
• premature death_Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0002083I129129P2OlaHsdFVBNRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0Rb1tm2BrnTgCol1a1cre1KryTrp53tm1Brn