Y Lucy. Liu, et.al., Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy., Blood, 2016, 127

http://rdf.ncbi.nlm.nih.gov/pubmed/26764354

Y Lucy. Liu, et.al., Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy., Blood, 2016, 127

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased T cell number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005018B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased liver weight_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002981B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• abnormal spleen morphology_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000689B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• decreased B cell number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005017B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased macrophage cell number_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005425B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• decreased hemoglobin content_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002874B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased monocyte cell number_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000220B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• premature death_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• thrombocytosis_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005505B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• premature death_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• increased tumor incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002020B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• decreased lymphocyte cell number_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005016B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• abnormal hematopoietic stem cell morphology_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004808B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• abnormal lung morphology_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001175B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• enlarged liver_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000599B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• decreased bone marrow cell number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000333B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased T cell acute lymphoblastic leukemia incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0014049B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• abnormal liver morphology_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000598B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• anemia_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• increased spleen weight_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004952B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• abnormal bone marrow morphology_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002397B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased macrophage cell number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005425B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased T cell acute lymphoblastic leukemia incidence_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0014049B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• enlarged spleen_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased granulocyte number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• abnormal hemopoiesis_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0013693B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• decreased lymphocyte cell number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005016B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased tumor incidence_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002020B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• abnormal liver size_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004848B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• increased granulocyte number_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• anemia_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• enlarged spleen_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• increased spleen weight_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004952B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• increased liver weight_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002981B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• increased monocyte cell number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000220B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• thrombocytosis_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005505B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• increased leukocyte cell number_Nf1<tm1Fcr>/Nf1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218B6CgTgMx1cre1CgnNf1tm1FcrPtentm1HwuNf1tm1FcrNf1Ptentm1HwuPtentm1HwuTgMx1cre1Cgn0Ptentm1HwuNf1Nf1tm1FcrTgMx1cre1Cgn
• decreased B cell number_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005017B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu
• decreased T cell number_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005018B6CgTgMx1cre1CgnPtentm1HwuPtentm1HwuPtentm1HwuTgMx1cre1Cgn0TgMx1cre1CgnPtentm1Hwu