Jie. Jiang, et.al., Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs., Neuron, 2016, 90

http://rdf.ncbi.nlm.nih.gov/pubmed/27112497

Jie. Jiang, et.al., Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs., Neuron, 2016, 90

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• 3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5779391
• Tg(C9orf72)450BLagi
  http://metadb.riken.jp/db/mgi_rdf/MGI:5776473

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spatial working memory_Tg(C9orf72)450BLagi/?
  http://metadb.riken.jp/0008428IC3HC57BL6TgC9orf72450BLagiTgC9orf72450BLagi
• decreased lymphocyte cell number_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0005016IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• enlarged spleen_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0000691IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• premature death_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0002083IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• loss of hippocampal neurons_Tg(C9orf72)450BLagi/?
  http://metadb.riken.jp/0003240IC3HC57BL6TgC9orf72450BLagiTgC9orf72450BLagi
• abnormal cervical lymph node morphology_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0002351IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• neuronal cytoplasmic inclusions_Tg(C9orf72)450BLagi/?
  http://metadb.riken.jp/0011975IC3HC57BL6TgC9orf72450BLagiTgC9orf72450BLagi
• abnormal lymph node cell ratio_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0008828IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• decreased hemoglobin content_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0002874IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• decreased body weight_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0001262IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• abnormal celiac lymph node morphology_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0009626IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• impaired coordination_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0001405IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• decreased hematocrit_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0000208IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• increased neutrophil cell number_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0000219IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• increased anxiety-related response_Tg(C9orf72)450BLagi/?
  http://metadb.riken.jp/0001363IC3HC57BL6TgC9orf72450BLagiTgC9orf72450BLagi
• impaired spatial learning_Tg(C9orf72)450BLagi/?
  http://metadb.riken.jp/0012307IC3HC57BL6TgC9orf72450BLagiTgC9orf72450BLagi
• enlarged cervical lymph nodes_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0008542IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi
• abnormal social investigation_3110043O21Rik<tm1Lagi>/3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/0001360IC57BL6C57BL6N3110043O21Riktm1Lagi3110043O21Riktm1Lagi3110043O21Riktm1Lagi

class

http://purl.org/net/cito/citesAsAuthority

• 3110043O21Rik<tm1Lagi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5779391
• Tg(C9orf72)450BLagi
  http://metadb.riken.jp/db/mgi_rdf/MGI:5776473