Chia-Yu. Chen, et.al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis., Human molecular genetics, 2016, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/27179789

Chia-Yu. Chen, et.al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis., Human molecular genetics, 2016, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ddx3x<tm1.1Lyou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5774968
• Ddx3x<tm1.2Lyou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5774969

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased embryonic tissue cell apoptosis_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0013504I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• abnormal developmental patterning_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0002084I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• abnormal cell physiology_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0005621I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• embryonic growth retardation_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0003984I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• abnormal neural tube closure_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0003720I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• embryonic lethality between implantation and placentation_Ddx3x<tm1.2Lyou>/Y
  http://metadb.riken.jp/0009850I129C57BL6Ddx3xtm12LyouYDdx3xtm12Lyou
• abnormal allantois morphology_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0001726I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• preweaning lethality, complete penetrance_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0011100I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• decreased trophoblast giant cell number_Ddx3x<tm1.2Lyou>/Y
  http://metadb.riken.jp/0001713I129C57BL6Ddx3xtm12LyouYDdx3xtm12Lyou
• small allantois_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0004559I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• abnormal myocardial trabeculae morphology_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0002189I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• hemorrhage_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0001914I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• embryonic growth retardation_Ddx3x<tm1.2Lyou>/Y
  http://metadb.riken.jp/0003984I129C57BL6Ddx3xtm12LyouYDdx3xtm12Lyou
• decreased spongiotrophoblast size_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0012099I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• abnormal placental labyrinth vasculature morphology_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0008803I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• small placenta_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0004259I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• embryonic growth retardation_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0003984I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• embryonic lethality prior to tooth bud stage_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0013293I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• ventricular septal defect_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0010402I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• microcephaly_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000433I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• abnormal spongiotrophoblast cell morphology_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0008959I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• abnormal trophoblast giant cell morphology_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0005033I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• embryonic lethality prior to organogenesis_Ddx3x<tm1.2Lyou>/Y
  http://metadb.riken.jp/0013292I129C57BL6Ddx3xtm12LyouYDdx3xtm12Lyou
• increased mitotic index_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0004760I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• edema_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0001785I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• abnormal head fold morphology_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0011257I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• abnormal cell cycle_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0003077I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• decreased trophoblast giant cell number_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0001713I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• abnormal brain development_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0000913I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• no abnormal phenotype detected_Ddx3x<tm1.1Lyou>/Ddx3x<+>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0002169I129C57BL6CBADdx3xtm11LyouDdx3xTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1AmcDdx3x
• abnormal placenta vasculature_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0003231I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• abnormal embryo turning_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0001700I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• pericardial effusion_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0005312I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• failure of chorioallantoic fusion_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0009657I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc
• lethality throughout fetal growth and development, incomplete penetrance_Ddx3x<tm1.2Lyou>/Ddx3x<+>
  http://metadb.riken.jp/0011109I129C57BL6Ddx3xtm12LyouDdx3xDdx3xDdx3xtm12Lyou
• preweaning lethality, complete penetrance_Ddx3x<tm1.1Lyou>/Y,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0011100I129C57BL6CBADdx3xtm11LyouYTgSox2cre1Amc0Ddx3xtm11LyouTgSox2cre1Amc

class

http://purl.org/net/cito/citesAsAuthority

• Ddx3x<tm1.1Lyou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5774968
• Ddx3x<tm1.2Lyou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5774969