Hyeseok. Shim, et.al., Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system., Proceedings of the National Academy of Sciences of the United States of America, 2016, 113

http://rdf.ncbi.nlm.nih.gov/pubmed/27313209

Hyeseok. Shim, et.al., Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system., Proceedings of the National Academy of Sciences of the United States of America, 2016, 113

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal circulating chemokine level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0010209IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased circulating interleukin-10 level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008593IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• decreased regulatory T cell number_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0004974IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• kidney inflammation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0001859IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• abnormal circulating protein level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0005416IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased interleukin-17 secretion_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008681IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased CD8-positive, alpha-beta T cell number_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008078IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased T-helper cell number_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0013763IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• chronic inflammation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0002499IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• salivary gland inflammation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0001870IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased inflammatory response_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0001846IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased circulating interleukin-12b level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008647IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased circulating interleukin-2 level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008599IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased CD4-positive, alpha beta T cell number_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008074IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased interferon-gamma secretion_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008566IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• lung inflammation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0001861IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased circulating interleukin-4 level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008602IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased circulating aspartate transaminase level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0005343IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• pale liver_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0000603IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• decreased blood urea nitrogen level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0005566IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• intestinal inflammation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0001858IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased circulating interleukin-12 level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008617IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• abnormal T cell activation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0001828IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• liver inflammation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0001860IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased T cell proliferation_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0005348IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased IgG3 level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008502IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi
• increased circulating interferon-gamma level_Pip4k2c<tm1b(KOMP)Wtsi>/Pip4k2c<tm1b(KOMP)Wtsi>
  http://metadb.riken.jp/0008577IC57BL6JC57BL6NPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsiPip4k2ctm1bKOMPWtsi