Teng. Zhang, et.al., Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin., Human molecular genetics, 2016, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/27522498

Teng. Zhang, et.al., Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin., Human molecular genetics, 2016, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Aggf1<tm1Qkw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5882327

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• lung hemorrhage_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0001182I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• embryonic lethality prior to organogenesis_Aggf1<Gt(PT036)Byg>/Aggf1<Gt(PT036)Byg>
  http://metadb.riken.jp/0013292I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1GtPT036BygAggf1GtPT036Byg
• abnormal vascular development_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0000259I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• abnormal vascular development_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0000259I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• abnormal vascular endothelial cell physiology_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0004003I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• decreased tumor incidence_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0002052I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• abnormal lung vasculature morphology_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0004007I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• abnormal vascular endothelial cell physiology_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0004003I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• abnormal vitelline vasculature morphology_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0003229I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• internal hemorrhage_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0001634I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• embryonic lethality, incomplete penetrance_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0011102I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• intracranial hemorrhage_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0001915I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• internal hemorrhage_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0001634I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• increased vascular permeability_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0003070I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• fatigue_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0002899I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• embryonic lethality, incomplete penetrance_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0011102I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• premature death_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• embryonic lethality prior to organogenesis_Aggf1<tm1Qkw>/Aggf1<tm1Qkw>
  http://metadb.riken.jp/0013292I129C57BL6Aggf1tm1QkwAggf1tm1QkwAggf1tm1Qkw
• lung hemorrhage_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0001182I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• abnormal tumor vascularization_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0010144I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• decreased tumor incidence_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0002052I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• abnormal vitelline vasculature morphology_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0003229I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• abnormal tumor vascularization_Aggf1<tm1Qkw>/Aggf1<+>
  http://metadb.riken.jp/0010144I129C57BL6Aggf1tm1QkwAggf1Aggf1tm1QkwAggf1
• increased vascular permeability_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0003070I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• abnormal brain vasculature morphology_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0004950I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1
• decreased lung endothelial cell migration_Aggf1<Gt(PT036)Byg>/Aggf1<+>
  http://metadb.riken.jp/0011134I129P2OlaHsdC57BL6Aggf1GtPT036BygAggf1Aggf1GtPT036BygAggf1

class

http://purl.org/net/cito/citesAsAuthority

• Aggf1<tm1Qkw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5882327