Gabriel. Balmus, et.al., Synthetic lethality between PAXX and XLF in mammalian development., Genes & development, 2016, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/27798842

Gabriel. Balmus, et.al., Synthetic lethality between PAXX and XLF in mammalian development., Genes & development, 2016, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Paxx<em1Spj>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5822837

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• lethality throughout fetal growth and development, incomplete penetrance_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0011109I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased B cell number_Atm<tm1Awb>/Atm<tm1Awb>,Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0005017IAJC57BL6NTacAtmtm1AwbAtmtm1AwbPaxxem1SpjPaxxem1SpjPaxxem1SpjAtmtm1Awb
• athymia_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0000705I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• abnormal thymus involution_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0001824I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased CD4-positive, alpha beta T cell number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0008075C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• decreased body size_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0001265I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased birth body size_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0009703I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased splenocyte number_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0009339I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• increased mature B cell number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0008210C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• decreased T cell number_Atm<tm1Awb>/Atm<tm1Awb>,Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0005018IAJC57BL6NTacAtmtm1AwbAtmtm1AwbPaxxem1SpjPaxxem1SpjPaxxem1SpjAtmtm1Awb
• decreased T cell number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0005018C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• decreased splenocyte number_Atm<tm1Awb>/Atm<tm1Awb>,Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0009339IAJC57BL6NTacAtmtm1AwbAtmtm1AwbPaxxem1SpjPaxxem1SpjPaxxem1SpjAtmtm1Awb
• decreased spleen weight_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0004953I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• increased mortality induced by gamma-irradiation_Atm<tm1Awb>/Atm<tm1Awb>
  http://metadb.riken.jp/0001658A129S6Atmtm1AwbJAtmtm1AwbAtmtm1AwbAtmtm1Awb
• decreased body size_Nhej1<tm1Fwa>/Nhej1<tm1Fwa>,Xrcc5<tm1Nus>/Xrcc5<tm1Nus>
  http://metadb.riken.jp/0001265I129S6SvEvTacC57BL6Nhej1tm1FwaNhej1tm1FwaXrcc5tm1NusXrcc5tm1NusXrcc5tm1NusNhej1tm1Fwa
• increased neural tube apoptosis_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0012505I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• abnormal class switch recombination_Atm<tm1Awb>/Atm<tm1Awb>,Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0004816IAJC57BL6NTacAtmtm1AwbAtmtm1AwbPaxxem1SpjPaxxem1SpjPaxxem1SpjAtmtm1Awb
• decreased CD8-positive, alpha-beta T cell number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0008079C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• athymia_Nhej1<tm1Fwa>/Nhej1<tm1Fwa>,Xrcc5<tm1Nus>/Xrcc5<tm1Nus>
  http://metadb.riken.jp/0000705I129S6SvEvTacC57BL6Nhej1tm1FwaNhej1tm1FwaXrcc5tm1NusXrcc5tm1NusXrcc5tm1NusNhej1tm1Fwa
• decreased fetal weight_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0009431I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased body weight_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0001262I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• postnatal lethality, incomplete penetrance_Paxx<em1Spj>/Paxx<em1Spj>,Xrcc5<tm1Nus>/Xrcc5<tm1Nus>
  http://metadb.riken.jp/0011086IC57BL6C57BL6NTacPaxxem1SpjPaxxem1SpjXrcc5tm1NusXrcc5tm1NusPaxxem1SpjXrcc5tm1Nus
• decreased embryo size_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0001698I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• chromosomal instability_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0008866I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• small spleen_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0000692I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased transitional stage B cell number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0008190C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• increased mortality induced by gamma-irradiation_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0001658C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• postnatal lethality, incomplete penetrance_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0011086I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased fetal size_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0004200I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased B cell number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0005017C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• absent lymphocyte_Paxx<em1Spj>/Paxx<em1Spj>,Nhej1<tm1Fwa>/Nhej1<tm1Fwa>
  http://metadb.riken.jp/0000726I129S6SvEvTacC57BL6NTacPaxxem1SpjPaxxem1SpjNhej1tm1FwaNhej1tm1FwaNhej1tm1FwaPaxxem1Spj
• decreased splenocyte number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0009339C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• decreased follicular B cell number_Paxx<em1Spj>/Paxx<em1Spj>
  http://metadb.riken.jp/0008174C57BL6NTacPaxxem1SpjPaxxem1SpjPaxxem1SpjPaxxem1Spj
• prenatal lethality, complete penetrance_Paxx<em1Spj>/Paxx<em1Spj>,Lig4<tm1Fwa>/Lig4<tm1Fwa>
  http://metadb.riken.jp/0011091I129S6SvEvTacC57BL6C57BL6NTacPaxxem1SpjPaxxem1SpjLig4tm1FwaLig4tm1FwaPaxxem1SpjLig4tm1Fwa
• small spleen_Nhej1<tm1Fwa>/Nhej1<tm1Fwa>,Xrcc5<tm1Nus>/Xrcc5<tm1Nus>
  http://metadb.riken.jp/0000692I129S6SvEvTacC57BL6Nhej1tm1FwaNhej1tm1FwaXrcc5tm1NusXrcc5tm1NusXrcc5tm1NusNhej1tm1Fwa

class

http://purl.org/net/cito/citesAsAuthority

• Paxx<em1Spj>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5822837