Shuaiyu. Wang, et.al., The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying., PLoS genetics, 2016, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/27911893

Shuaiyu. Wang, et.al., The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying., PLoS genetics, 2016, 12

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Afg3l1<tm1.1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5817724

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased melanocyte number_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0012023I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• abnormal mitochondrial shape_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0011633I129S1Sv129X1SvJC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0TgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1LrsnAfg3l2tm1Arte
• impaired coordination_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0001405IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• dilated mitochondria_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0011632I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• abnormal oligodendrocyte morphology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0000953I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• abnormal Schwann cell morphology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0001106I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• demyelination_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0000921I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• increased mitochondria size_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0011630IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• dilated mitochondria_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0011632I129S1Sv129X1SvJC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0TgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1LrsnAfg3l2tm1Arte
• impaired coordination_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0001405IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• decreased body fat mass_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0014143IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• increased myelin sheath thickness_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0011730IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• abnormal oligodendrocyte physiology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0008917I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• astrocytosis_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0003354IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• abnormal brain white matter morphology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0008026IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• abnormal spinal cord white matter morphology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0008027IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• abnormal mitochondrial physiology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0006036I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• decreased myelin sheath thickness_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0011731IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• microgliosis_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0008918IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• dysmyelination_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0013438IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• abnormal melanoblast morphology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0009783I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• abnormal sciatic nerve morphology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0002651I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn
• demyelination_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0000921IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• abnormal spinal cord white matter morphology_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0008027IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• abnormal mitochondrial crista morphology_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0011635IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• axon degeneration_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0005405IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• abnormal oligodendrocyte morphology_Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0000953IC57BL6JAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l2tm1ArteTgPlp1creERT3Pop
• abnormal coat/hair pigmentation_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0002075IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• decreased body weight_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0001262IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• axon degeneration_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0005405IC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3Pop
• abnormal dermal layer morphology_Afg3l1<tm1.1Arte>/Afg3l1<tm1.1Arte>,Afg3l2<tm1Arte>/Afg3l2<tm1Arte>,Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Tg(Plp1-cre/ERT)3Pop/0
  http://metadb.riken.jp/0001243I129S1Sv129X1SvJC57BL6JC57BL6NAfg3l1tm11ArteAfg3l1tm11ArteAfg3l2tm1ArteAfg3l2tm1ArteGtROSA26Sortm1LrsnGtROSA26SorTgPlp1creERT3Pop0Afg3l1tm11ArteAfg3l2tm1ArteTgPlp1creERT3PopGtROSA26SorGtROSA26Sortm1Lrsn

class

http://purl.org/net/cito/citesAsAuthority

• Afg3l1<tm1.1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5817724