Gernot. Kleinberger, et.al., The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism., The EMBO journal, 2017, 36

http://rdf.ncbi.nlm.nih.gov/pubmed/28559417

Gernot. Kleinberger, et.al., The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism., The EMBO journal, 2017, 36

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Trem2<em1Bwef>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5818272

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired macrophage phagocytosis_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0001798IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• increased macrophage apoptosis_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0011080IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• increased susceptibility to endotoxin shock_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0008735IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• decreased macrophage proliferation_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0011986IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• abnormal microglial cell activation_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0010762IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• abnormal blood volume_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0001599IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• decreased macrophage cell number_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0003884IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• increased circulating tumor necrosis factor level_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0008553IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• increased circulating interleukin-6 level_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0008596IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef
• decreased macrophage cell number_Trem2<em1Bwef>/Trem2<+>
  http://metadb.riken.jp/0003884IC57BL6JDBA2JFVBNTrem2em1BwefTrem2Trem2em1BwefTrem2
• abnormal glucose homeostasis_Trem2<em1Bwef>/Trem2<em1Bwef>
  http://metadb.riken.jp/0002078IC57BL6JDBA2JFVBNTrem2em1BwefTrem2em1BwefTrem2em1Bwef

class

http://purl.org/net/cito/citesAsAuthority

• Trem2<em1Bwef>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5818272