M E. Fabry, et.al., A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity., Blood, 1995, 86

http://rdf.ncbi.nlm.nih.gov/pubmed/7662990

M E. Fabry, et.al., A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity., Blood, 1995, 86

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal kidney afferent arteriole morphology_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0011312IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• renal fibrosis_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0003985IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal erythrocyte morphology_Hbb<d3th>/Hbb<+>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002447IFVBNSwissWebsterHbbd3thHbbTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgLCRHBA2LCRHBB11CosHbbTgHBBARHBA2HBB58RubHbbd3th
• increased spleen red pulp amount_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0008476IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal brain morphology_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002152IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• pulmonary interstitial fibrosis_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0003426IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• enlarged spleen_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0000691IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal hemoglobin_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0001588IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• spleen vascular congestion_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0010020IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• enlarged kidney_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0003068IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• glomerular capillary congestion_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0011433IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• premature death_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002083IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• increased circulating aspartate transaminase level_Hbb<d3th>/Hbb<+>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0005343IFVBNSwissWebsterHbbd3thHbbTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgLCRHBA2LCRHBB11CosHbbTgHBBARHBA2HBB58RubHbbd3th
• increased mean corpuscular hemoglobin_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0005561IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• increased circulating aspartate transaminase level_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0005343IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• anemia_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0001577IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• brain vascular congestion_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0010022IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal erythrocyte morphology_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002447IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• anemia_Hbb<d3th>/Hbb<+>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0001577IFVBNSwissWebsterHbbd3thHbbTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgLCRHBA2LCRHBB11CosHbbTgHBBARHBA2HBB58RubHbbd3th
• abnormal spleen morphology_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0000689IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• reticulocytosis_Hbb<d3th>/Hbb<+>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002640IFVBNSwissWebsterHbbd3thHbbTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgLCRHBA2LCRHBB11CosHbbTgHBBARHBA2HBB58RubHbbd3th
• reticulocytosis_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0
  http://metadb.riken.jp/0002640ISwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgHBBARHBA2HBB58RubHbbd3th
• increased circulating alanine transaminase level_Hbb<d3th>/Hbb<+>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002941IFVBNSwissWebsterHbbd3thHbbTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgLCRHBA2LCRHBB11CosHbbTgHBBARHBA2HBB58RubHbbd3th
• reticulocytosis_Hbb<d3th>/Hbb<d3th>,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002640IFVBNHbbd3thHbbd3thTgLCRHBA2LCRHBB11Cos0Hbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal erythrocyte morphology_Hbb<d3th>/Hbb<d3th>,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002447IFVBNHbbd3thHbbd3thTgLCRHBA2LCRHBB11Cos0Hbbd3thTgLCRHBA2LCRHBB11Cos
• increased mean corpuscular hemoglobin_Hbb<d3th>/Hbb<d3th>,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0005561IFVBNHbbd3thHbbd3thTgLCRHBA2LCRHBB11Cos0Hbbd3thTgLCRHBA2LCRHBB11Cos
• decreased urine osmolality_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002988IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal urine homeostasis_Hbb<d3th>/Hbb<+>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0009643IFVBNSwissWebsterHbbd3thHbbTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgLCRHBA2LCRHBB11CosHbbTgHBBARHBA2HBB58RubHbbd3th
• postnatal lethality_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002082IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• pulmonary alveolar hemorrhage_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0010909IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal urine homeostasis_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0009643IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal neuron morphology_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002882IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• reticulocytosis_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002640IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• enlarged liver_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0000599IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• abnormal liver morphology_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0000598IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• spleen fibrosis_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0011746IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• liver fibrosis_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0003333IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• thick pulmonary interalveolar septum_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0001179IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• pulmonary vascular congestion_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0010018IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• increased circulating alanine transaminase level_Hbb<d3th>/Hbb<d3th>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002941IFVBNSwissWebsterHbbd3thHbbd3thTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgHBBARHBA2HBB58RubHbbd3thTgLCRHBA2LCRHBB11Cos
• decreased urine osmolality_Hbb<d3th>/Hbb<+>,Tg(HBB-AR-HBA2,-HBB*)58Rub/0,Tg(LCR-HBA2,LCR-HBB)11Cos/0
  http://metadb.riken.jp/0002988IFVBNSwissWebsterHbbd3thHbbTgHBBARHBA2HBB58Rub0TgLCRHBA2LCRHBB11Cos0TgLCRHBA2LCRHBB11CosHbbTgHBBARHBA2HBB58RubHbbd3th