A. Grossmann, et.al., Pathologic features associated with decreased longevity of mutant sphha/sphha mice with chronic hemolytic anemia: similarities to sequelae of sickle cell anemia in humans., Laboratory animal science, 1993, 43

http://rdf.ncbi.nlm.nih.gov/pubmed/8355480

A. Grossmann, et.al., Pathologic features associated with decreased longevity of mutant sphha/sphha mice with chronic hemolytic anemia: similarities to sequelae of sickle cell anemia in humans., Laboratory animal science, 1993, 43

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating bilirubin level_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0005344EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• extramedullary hematopoiesis_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0000240EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased susceptibility to bacterial infection_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0002412EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• premature death_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0002083EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased bone marrow cell number_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0000321EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• gallstones_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0002830EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• lymph node hyperplasia_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0008102EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• abnormal lung morphology_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0001175EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased neutrophil cell number_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0000219EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• abnormal pulmonary alveolus wall morphology_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0010903EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• hemosiderosis_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0005639EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased leukocyte cell number_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0000218EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased IgG level_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0002493EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• hemolytic anemia_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0001585EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• vasculature congestion_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0000255EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• pulmonary fibrosis_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0006050EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• abnormal thrombosis_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0005048EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• alveolitis_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0010922EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased IgA level_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0002495EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• interstitial pneumonia_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0001862EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased monocyte cell number_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0000220EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha
• increased lymphocyte cell number_Spta1<sph-ha>/Spta1<sph-ha>
  http://metadb.riken.jp/0005013EB6D1Spta1sphhaxWBD1Spta1sphhaF1orWBD1Spta1sphhaxB6D1Spta1sphhaF1Spta1sphhaSpta1sphhaSpta1sphha