T. Matsuyama, et.al., Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development., Cell, 1993, 75

http://rdf.ncbi.nlm.nih.gov/pubmed/8402903

T. Matsuyama, et.al., Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development., Cell, 1993, 75

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Irf2<tm1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2175949
• Irf1<tm1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1857205

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• no abnormal phenotype detected_Irf2<tm1Mak>/Irf2<+>
  http://metadb.riken.jp/0002169EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2Irf2tm1MakIrf2
• increased CD4-positive, alpha beta T cell number_Irf1<tm1Mak>/Irf1<tm1Mak>
  http://metadb.riken.jp/0008074EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf1tm1MakIrf1tm1MakIrf1tm1Mak
• decreased IgG2a level_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0008496EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak
• abnormal immune system physiology_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0001790EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak
• decreased T cell number_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0005018EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak
• skin lesions_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0001212EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak
• abnormal response to infection_Irf1<tm1Mak>/Irf1<tm1Mak>
  http://metadb.riken.jp/0005025EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf1tm1MakIrf1tm1MakIrf1tm1Mak
• decreased B cell proliferation_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0005093EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak
• abnormal T cell number_Irf1<tm1Mak>/Irf1<tm1Mak>
  http://metadb.riken.jp/0006387EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf1tm1MakIrf1tm1MakIrf1tm1Mak
• no abnormal phenotype detected_Irf1<tm1Mak>/Irf1<+>
  http://metadb.riken.jp/0002169EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf1tm1MakIrf1Irf1Irf1tm1Mak
• increased double-positive T cell number_Irf1<tm1Mak>/Irf1<tm1Mak>
  http://metadb.riken.jp/0005091EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf1tm1MakIrf1tm1MakIrf1tm1Mak
• decreased mature B cell number_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0008211EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak
• decreased CD8-positive, alpha-beta T cell number_Irf1<tm1Mak>/Irf1<tm1Mak>
  http://metadb.riken.jp/0008079EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf1tm1MakIrf1tm1MakIrf1tm1Mak
• abnormal response to infection_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0005025EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak
• premature death_Irf2<tm1Mak>/Irf2<tm1Mak>
  http://metadb.riken.jp/0002083EI129S2SvPasC57BL6JorI129S2SvPasC57BL6JDBA2Irf2tm1MakIrf2tm1MakIrf2tm1Mak

class

http://purl.org/net/cito/citesAsAuthority

• Irf2<tm1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2175949
• Irf1<tm1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1857205