E J. Kelly, et.al., A murine model of Menkes disease reveals a physiological function of metallothionein., Nature genetics, 1996, 13

http://rdf.ncbi.nlm.nih.gov/pubmed/8640230

E J. Kelly, et.al., A murine model of Menkes disease reveals a physiological function of metallothionein., Nature genetics, 1996, 13

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• embryonic lethality, complete penetrance_Atp7a<Mo-brJ>/Atp7a<+>,Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0011092I129S7SvEvBrdC3HHeJAtp7aMobrJAtp7aMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt2tm1BriAtp7aMobrJAtp7aMt1tm1Bri
• abnormal coat/hair pigmentation_Atp7a<Mo-brJ>/Y
  http://metadb.riken.jp/0002075IC3HHeJC57BL6JAtp7aMobrJYAtp7aMobrJ
• increased sensitivity to induced cell death_Atp7a<Mo-brJ>/Atp7a<+>,Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0008943I129S7SvEvBrdC3HHeJAtp7aMobrJAtp7aMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt2tm1BriAtp7aMobrJAtp7aMt1tm1Bri
• no abnormal phenotype detected_Atp7a<Mo-brJ>/Atp7a<+>,Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>,Tg(Mt1)174Bri/0
  http://metadb.riken.jp/0002169I129S7SvEvBrdC3HHeJC57BL6SJLAtp7aMobrJAtp7aMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriTgMt1174Bri0Mt1tm1BriTgMt1174BriAtp7aAtp7aMobrJMt2tm1Bri
• postnatal lethality_Atp7a<Mo-brJ>/Y
  http://metadb.riken.jp/0002082IC3HHeJC57BL6JAtp7aMobrJYAtp7aMobrJ
• abnormal gait_Atp7a<Mo-brJ>/Y
  http://metadb.riken.jp/0001406IC3HHeJC57BL6JAtp7aMobrJYAtp7aMobrJ
• increased intestine copper level_Atp7a<Mo-brJ>/Y
  http://metadb.riken.jp/0010247IC3HHeJC57BL6JAtp7aMobrJYAtp7aMobrJ
• decreased liver copper level_Atp7a<Mo-brJ>/Y
  http://metadb.riken.jp/0003067IC3HHeJC57BL6JAtp7aMobrJYAtp7aMobrJ
• tremors_Atp7a<Mo-brJ>/Y
  http://metadb.riken.jp/0000745IC3HHeJC57BL6JAtp7aMobrJYAtp7aMobrJ
• postnatal lethality, complete penetrance_Atp7a<Mo-brJ>/Y,Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0011085I129S7SvEvBrdC3HHeJC57BL6JAtp7aMobrJYMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriAtp7aMobrJMt2tm1BriMt1tm1Bri
• mottled coat_Atp7a<Mo-brJ>/Y
  http://metadb.riken.jp/0000421IC3HHeJC57BL6JAtp7aMobrJYAtp7aMobrJ
• increased sensitivity to induced cell death_Atp7a<Mo-brJ>/Y,Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0008943I129S7SvEvBrdC3HHeJC57BL6JAtp7aMobrJYMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriAtp7aMobrJMt2tm1BriMt1tm1Bri
• increased sensitivity to induced cell death_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0008943I129S7SvEvBrdMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri
• decreased body size_Atp7a<Mo-brJ>/Atp7a<+>,Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0001265I129S7SvEvBrdC3HHeJAtp7aMobrJAtp7aMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt2tm1BriAtp7aMobrJAtp7aMt1tm1Bri
• embryonic lethality during organogenesis, incomplete penetrance_Atp7a<Mo-brJ>/Y,Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0011108I129S7SvEvBrdC3HHeJC57BL6JAtp7aMobrJYMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriAtp7aMobrJMt2tm1BriMt1tm1Bri