T. Ludwig, et.al., Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos., Genes & development, 1997, 11

http://rdf.ncbi.nlm.nih.gov/pubmed/9171368

T. Ludwig, et.al., Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos., Genes & development, 1997, 11

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Brca1<tm1Arge>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930613
• Brca2<tm1Arge>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930615

class

http://purl.org/net/cito/citesAsAuthority

• Brca1<tm1Arge>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930613
• Brca2<tm1Arge>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930615

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• embryonic lethality, complete penetrance_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0011092I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge
• enlarged allantois_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0004556I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge
• abnormal embryonic tissue morphology_Brca2<tm1Arge>/Brca2<tm1Arge>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002085I129SSvEv129S2SvPasC57BL6Brca2tm1ArgeBrca2tm1ArgeTrp53tm1TyjTrp53tm1TyjBrca2tm1ArgeTrp53tm1Tyj
• abnormal amnion morphology_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0005029I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge
• abnormal extraembryonic tissue morphology_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0002086I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge
• absent mesoderm_Brca1<tm1Arge>/Brca1<tm1Arge>
  http://metadb.riken.jp/0001683I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca1tm1Arge
• abnormal embryo development_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0001672I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge
• abnormal embryonic tissue morphology_Brca1<tm1Arge>/Brca1<tm1Arge>
  http://metadb.riken.jp/0002085I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca1tm1Arge
• embryonic lethality, complete penetrance_Brca1<tm1Arge>/Brca1<tm1Arge>,Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0011092I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca2tm1ArgeBrca2tm1ArgeBrca1tm1ArgeBrca2tm1Arge
• empty decidua capsularis_Brca1<tm1Arge>/Brca1<tm1Arge>
  http://metadb.riken.jp/0009687I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca1tm1Arge
• prenatal lethality_Brca2<tm1Arge>/Brca2<tm1Arge>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002080I129SSvEv129S2SvPasC57BL6Brca2tm1ArgeBrca2tm1ArgeTrp53tm1TyjTrp53tm1TyjBrca2tm1ArgeTrp53tm1Tyj
• no abnormal phenotype detected_Brca1<tm1Arge>/Brca1<+>
  http://metadb.riken.jp/0002169I129SSvEvC57BL6Brca1tm1ArgeBrca1Brca1tm1ArgeBrca1
• abnormal embryonic tissue morphology_Brca1<tm1Arge>/Brca1<tm1Arge>,Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0002085I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca2tm1ArgeBrca2tm1ArgeBrca1tm1ArgeBrca2tm1Arge
• prenatal lethality_Brca1<tm1Arge>/Brca1<tm1Arge>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002080I129SSvEv129S2SvPasC57BL6Brca1tm1ArgeBrca1tm1ArgeTrp53tm1TyjTrp53tm1TyjTrp53tm1TyjBrca1tm1Arge
• abnormal visceral yolk sac morphology_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0001718I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge
• abnormal proamniotic cavity morphology_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0011197I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge
• absent amniotic folds_Brca1<tm1Arge>/Brca1<tm1Arge>
  http://metadb.riken.jp/0001710I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca1tm1Arge
• exencephaly_Brca2<tm1Arge>/Brca2<tm1Arge>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0000914I129SSvEv129S2SvPasC57BL6Brca2tm1ArgeBrca2tm1ArgeTrp53tm1TyjTrp53tm1TyjBrca2tm1ArgeTrp53tm1Tyj
• embryonic lethality, complete penetrance_Brca1<tm1Arge>/Brca1<tm1Arge>
  http://metadb.riken.jp/0011092I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca1tm1Arge
• embryonic growth retardation_Brca1<tm1Arge>/Brca1<tm1Arge>
  http://metadb.riken.jp/0003984I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca1tm1Arge
• embryonic growth retardation_Brca1<tm1Arge>/Brca1<tm1Arge>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003984I129SSvEv129S2SvPasC57BL6Brca1tm1ArgeBrca1tm1ArgeTrp53tm1TyjTrp53tm1TyjTrp53tm1TyjBrca1tm1Arge
• abnormal egg cylinder morphology_Brca1<tm1Arge>/Brca1<tm1Arge>
  http://metadb.riken.jp/0003085I129SSvEvC57BL6Brca1tm1ArgeBrca1tm1ArgeBrca1tm1Arge
• decreased embryo size_Brca2<tm1Arge>/Brca2<tm1Arge>
  http://metadb.riken.jp/0001698I129SSvEvC57BL6Brca2tm1ArgeBrca2tm1ArgeBrca2tm1Arge