C. Pászty, et.al., Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease., Science (New York, N.Y.), 1997, 278

http://rdf.ncbi.nlm.nih.gov/pubmed/9346488

C. Pászty, et.al., Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease., Science (New York, N.Y.), 1997, 278

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(HBA-HBBs)41Paz
  http://metadb.riken.jp/db/mgi_rdf/MGI:3056733

class

http://purl.org/net/cito/citesAsAuthority

• Tg(HBA-HBBs)41Paz
  http://metadb.riken.jp/db/mgi_rdf/MGI:3056733

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal erythrocyte osmotic lysis_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0003657I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• spleen vascular congestion_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0010020I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• increased spleen weight_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0004952I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• increased kidney weight_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0003917I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• anisopoikilocytosis_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0002641I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• abnormal hemoglobin_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0001588I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• increased kidney iron level_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0010375I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• neonatal lethality, incomplete penetrance_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0011088I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• kidney atrophy_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0004970I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• abnormal kidney blood vessel morphology_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0000530I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• decreased mean corpuscular hemoglobin_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0005562I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• hypoxia_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0005039I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• abnormal erythrocyte morphology_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0002447I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• increased heart weight_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0002833I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• decreased mean corpuscular hemoglobin concentration_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0005642I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• anemia_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0001577I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• decreased mean corpuscular volume_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0002591I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• kidney cysts_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0003675I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• abnormal liver vasculature morphology_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0009820I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• reticulocytosis_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0002640I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• abnormal lung vasculature morphology_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0004007I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• decreased hematocrit_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0000208I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• renal fibrosis_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0003985I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz
• increased liver iron level_Hba<tm1Paz>/Hba<tm1Paz>,Hbb<tm1Tow>/Hbb<tm1Tow>,Tg(HBA-HBBs)41Paz/?
  http://metadb.riken.jp/0008807I129S2SvPas129S7SvEvBrdBlackSwissC57BL6DBA2FVBNHbatm1PazHbatm1PazHbbtm1TowHbbtm1TowTgHBAHBBs41PazHbbtm1TowTgHBAHBBs41PazHbatm1Paz