M R. Blackburn, et.al., Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency., The Journal of biological chemistry, 1998, 273

http://rdf.ncbi.nlm.nih.gov/pubmed/9478961

M R. Blackburn, et.al., Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency., The Journal of biological chemistry, 1998, 273

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(PLADA)4118Rkmb
  http://metadb.riken.jp/db/mgi_rdf/MGI:2683027

class

http://purl.org/net/cito/citesAsAuthority

• Tg(PLADA)4118Rkmb
  http://metadb.riken.jp/db/mgi_rdf/MGI:2683027

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• spleen hypoplasia_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0000694I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• abnormal thymus corticomedullary boundary morphology_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0009543I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• decreased immunoglobulin level_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0002460I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• anemia_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0001577I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• tachypnea_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0005426I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• increased macrophage cell number_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0005425I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• small spleen_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0000692I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• abnormal renal tubule morphology_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0002703I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• decreased double-positive T cell number_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0005092I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• lung inflammation_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0001861I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• increased double-negative T cell number_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0005090I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• abnormal spleen red pulp morphology_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0002356I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• abnormal renal glomerulus morphology_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0005325I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• postnatal lethality, complete penetrance_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0011085I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• increased granulocyte number_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0000322I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• increased eosinophil cell number_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0005011I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• small thymus_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0000706I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• abnormal rib morphology_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0000150I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw
• decreased leukocyte cell number_Ada<tm1Mw>/Ada<tm1Mw>,Tg(PLADA)4118Rkmb/0
  http://metadb.riken.jp/0000221I129S7SvEvBrdC57BL6Adatm1MwAdatm1MwTgPLADA4118Rkmb0TgPLADA4118RkmbAdatm1Mw