M. Nomura, et.al., Smad2 role in mesoderm formation, left-right patterning and craniofacial development., Nature, 1998, 393

http://rdf.ncbi.nlm.nih.gov/pubmed/9655392

M. Nomura, et.al., Smad2 role in mesoderm formation, left-right patterning and craniofacial development., Nature, 1998, 393

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smad2<tm1Enl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1857692
• Smad2<tm2Enl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1857693

class

http://purl.org/net/cito/citesAsAuthority

• Smad2<tm1Enl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1857692
• Smad2<tm2Enl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:1857693

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• transposition of great arteries_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0004110I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• abnormal lateral plate mesoderm morphology_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0010117I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• abnormal craniofacial morphology_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0000428I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• abnormal rostral-caudal axis patterning_Smad2<tm2Enl>/Smad2<tm2Enl>
  http://metadb.riken.jp/0005221I129S4SvJaeSmad2tm2EnlSmad2tm2EnlSmad2tm2Enl
• abnormal developmental patterning_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0002084I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• abnormal eye development_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0001286I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• abnormal visceral endoderm morphology_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0011186I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• absent amnion_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0005030I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• abnormal mandible morphology_Smad2<tm2Enl>/Smad2<+>
  http://metadb.riken.jp/0000458I129S4SvJaeSmad2tm2EnlSmad2Smad2Smad2tm2Enl
• abnormal extraembryonic endoderm formation_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0001724I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• abnormal proamniotic cavity morphology_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0011197I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• decreased embryo size_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0001698I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• embryonic lethality, complete penetrance_Smad2<tm2Enl>/Smad2<tm2Enl>
  http://metadb.riken.jp/0011092I129S4SvJaeSmad2tm2EnlSmad2tm2EnlSmad2tm2Enl
• absent mesoderm_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0001683I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• embryonic lethality, complete penetrance_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0011092I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• abnormal primitive streak elongation_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0012685I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• abnormal proximal-distal axis patterning_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0001705I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• abnormal direction of embryo turning_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0004190I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• abnormal embryonic tissue morphology_Smad2<tm2Enl>/Smad2<+>
  http://metadb.riken.jp/0002085I129S4SvJaeSmad2tm2EnlSmad2Smad2Smad2tm2Enl
• embryonic growth retardation_Smad2<tm2Enl>/Smad2<+>
  http://metadb.riken.jp/0003984I129S4SvJaeSmad2tm2EnlSmad2Smad2Smad2tm2Enl
• abnormal gastrulation_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0001695I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• mandible hypoplasia_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0000460I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• absent mandible_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0000087I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• abnormal craniofacial morphology_Smad2<tm2Enl>/Smad2<+>
  http://metadb.riken.jp/0000428I129S4SvJaeSmad2tm2EnlSmad2Smad2Smad2tm2Enl
• abnormal embryonic tissue morphology_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0002085I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• right pulmonary isomerism_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0000531I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• embryonic growth retardation_Smad2<tm2Enl>/Smad2<tm2Enl>
  http://metadb.riken.jp/0003984I129S4SvJaeSmad2tm2EnlSmad2tm2EnlSmad2tm2Enl
• embryonic growth retardation_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0003984I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• embryonic growth retardation_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0003984I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• abnormal rostral-caudal axis patterning_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0005221I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• cyclopia_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0005163I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• abnormal extraembryonic tissue morphology_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0002086I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• abnormal craniofacial morphology_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0000428I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• abnormal mandible morphology_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0000458I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• absent allantois_Smad2<tm1Enl>/Smad2<+>
  http://metadb.riken.jp/0003087I129S4SvJaeSmad2tm1EnlSmad2Smad2Smad2tm1Enl
• abnormal embryonic-extraembryonic boundary morphology_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0003890I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• rostral body truncation_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0012157I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• abnormal heart looping_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0000269I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• failure of primitive streak formation_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0001693I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl
• abnormal eye development_Smad2<tm2Enl>/Smad2<+>
  http://metadb.riken.jp/0001286I129S4SvJaeSmad2tm2EnlSmad2Smad2Smad2tm2Enl
• abnormal left-right axis patterning_Smad2<tm1Enl>/Smad2<+>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0001706I129SSvEv129S4SvJaeSmad2tm1EnlSmad2Nodaltm1RobNodalNodalNodaltm1RobSmad2Smad2tm1Enl
• abnormal embryonic epiblast morphology_Smad2<tm1Enl>/Smad2<tm1Enl>
  http://metadb.riken.jp/0003886I129S4SvJaeSmad2tm1EnlSmad2tm1EnlSmad2tm1Enl