neuron degeneration_Htt<tm1Mfc>/Htt<+>,Ppargc1a<tm1Dpk>/Ppargc1a<+>

http://metadb.riken.jp/0003224I129S1Sv129X1SvJHtttm1MfcHttPpargc1atm1DpkPpargc1aHttPpargc1atm1DpkPpargc1aHtttm1Mfc

neuron degeneration_Htt<tm1Mfc>/Htt<+>,Ppargc1a<tm1Dpk>/Ppargc1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• huntingtin
  http://metadb.riken.jp/db/mgi_rdf/MGI:96067
• peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:1342774

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Htt<tm1Mfc>/Htt<+>,Ppargc1a<tm1Dpk>/Ppargc1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Htt<+>|Ppargc1a<tm1Dpk>|Ppargc1a<+>|Htt<tm1Mfc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• neuron degeneration
  http://purl.obolibrary.org/obo/MP_0003224

文献

http://purl.org/net/cito/citesAsAuthority

• Libin. Cui, et.al., Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration., Cell, 2006, 127
  http://rdf.ncbi.nlm.nih.gov/pubmed/17018277