Leilei. Yang, et.al., Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors., Cancer research, 2005, 65

http://rdf.ncbi.nlm.nih.gov/pubmed/16204035

Leilei. Yang, et.al., Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors., Cancer research, 2005, 65

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hair follicle outer rooth sheath hyperplasia in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020082
• epidermal hyperplasia in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020032

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal keratinocyte physiology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0003453I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• increased keratinocyte proliferation_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0009583I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• hair follicle outer rooth sheath hyperplasia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0010688I129P2OlaHsdPtentm2MakPtentm2MakTgKRT5cre1Xya0TgKRT5cre1XyaPtentm2Mak
• thick epidermis stratum basale_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0009715I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• increased keratinocyte proliferation_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0009583I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• hyperkeratosis_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0001242I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• enlarged hair follicles_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0000381I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• increased skin papilloma incidence_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002051I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• epithelioid cysts_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002015I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• abnormal hair follicle regression_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0003875I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• premature death_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• increased stomach tumor incidence_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0010301I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• abnormal keratinocyte morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002655I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• abnormal hypodermis morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0003705I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• epidermal hyperplasia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0001222I129P2OlaHsdPtentm2MakPtentm2MakTgKRT5cre1Xya0TgKRT5cre1XyaPtentm2Mak
• abnormal hair follicle regression_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0003875I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• abnormal hair follicle morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0000377I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• premature death_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002083I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• thick hair follicle outer rooth sheath_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0010690I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• alopecia_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0000414I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• alopecia_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0000414I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• increased skin tumor incidence_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0010300I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• thick skin_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0001200I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• increased skin tumor incidence_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0010300I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• thick hair follicle outer rooth sheath_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0010690I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• thick epidermis_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0001219I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• abnormal hair follicle morphology_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0000377I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• decreased tumor latency_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0010308I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• abnormal skin appearance_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0009931I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya
• increased carcinoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002038I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• increased skin papilloma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002051I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• thick epidermis_Pten<tm2Mak>/Pten<tm2Mak>,Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0001219I129P2OlaHsd129S6SvEvTacPtentm2MakPtentm2MakSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Ptentm2MakTgKRT5cre1XyaSmad4tm21Cxd
• increased carcinoma incidence_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(KRT5-cre)1Xya/0
  http://metadb.riken.jp/0002038I129S6SvEvTacSmad4tm21CxdSmad4tm21CxdTgKRT5cre1Xya0Smad4tm21CxdTgKRT5cre1Xya