Laura. Bordone, et.al., SIRT1 transgenic mice show phenotypes resembling calorie restriction., Aging cell, 2007, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/17877786

Laura. Bordone, et.al., SIRT1 transgenic mice show phenotypes resembling calorie restriction., Aging cell, 2007, 6

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• male infertility in RBRC05323
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010958
• decreased body weight in RBRC05323
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010768
• eyelids fail to open in RBRC05323
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010770
• decreased body size in RBRC05323
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010769
• female infertility in RBRC05323
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1008054

allele

http://purl.org/net/cito/citesAsAuthority

• Actb<tm3.1(Sirt1)Npa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4456082

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal eating behavior_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0001431I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased circulating cholesterol level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0005179I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• delayed fertility_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0002683I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• preweaning lethality, incomplete penetrance_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0011110I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased circulating HDL cholesterol level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0000186I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased body size_Sirt1<tm1Mcby>/Sirt1<tm1Mcby>
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJSirt1tm1McbySirt1tm1McbySirt1tm1Mcby
• eyelids fail to open_Sirt1<tm1Mcby>/Sirt1<tm1Mcby>
  http://metadb.riken.jp/0005176I129S1Sv129X1SvJSirt1tm1McbySirt1tm1McbySirt1tm1Mcby
• decreased circulating LDL cholesterol level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0000183I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased body weight_Sirt1<tm1Mcby>/Sirt1<tm1Mcby>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJSirt1tm1McbySirt1tm1McbySirt1tm1Mcby
• abnormal motor coordination/ balance_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0001516I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased circulating leptin level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0005668I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• male infertility_Sirt1<tm1Mcby>/Sirt1<tm1Mcby>
  http://metadb.riken.jp/0001925I129S1Sv129X1SvJSirt1tm1McbySirt1tm1McbySirt1tm1Mcby
• decreased circulating glucose level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0005560I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased body weight_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0001262I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• preweaning lethality, complete penetrance_Actb<tm3.1(Sirt1)Npa>/Actb<tm3.1(Sirt1)Npa>
  http://metadb.riken.jp/0011100I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbtm31Sirt1NpaActbtm31Sirt1Npa
• female infertility_Sirt1<tm1Mcby>/Sirt1<tm1Mcby>
  http://metadb.riken.jp/0001926I129S1Sv129X1SvJSirt1tm1McbySirt1tm1McbySirt1tm1Mcby
• decreased circulating insulin level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0002727I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased adiponectin level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0004893I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• improved glucose tolerance_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0005292I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased circulating free fatty acid level_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0002702I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• increased oxygen consumption_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0005289I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb
• decreased epididymal fat pad weight_Actb<tm3.1(Sirt1)Npa>/Actb<+>
  http://metadb.riken.jp/0009289I129SvC57BL6C57BL6JActbtm31Sirt1NpaActbActbtm31Sirt1NpaActb