Eran. Elinav, et.al., NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis., Cell, 2011, 145

http://rdf.ncbi.nlm.nih.gov/pubmed/21565393

http://rdf.ncbi.nlm.nih.gov/pubmed/21565393

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased susceptibility to induced colitis in RBRC00957
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001653
• abnormal gut flora balance in RBRC00957
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001659

allele

http://purl.org/net/cito/citesAsAuthority

• Nlrp10<tm1Seis>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085851
• Nlrp6<tm1Flv>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085850

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal gut flora balance_Casp1<tm1Flv>/Casp1<tm1Flv>,Casp4<del>/Casp4<del>
  http://metadb.riken.jp/0010377B6129S2Casp1tm1FlvCasp1tm1FlvCasp1tm1FlvCasp4delCasp4delCasp4delCasp1tm1Flv
• abnormal gut flora balance_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0010377B6129S5Pycardtm1FlvPycardtm1FlvPycardtm1FlvPycardtm1Flv
• abnormal gut flora balance_Il18<tm1Aki>/Il18<tm1Aki>
  http://metadb.riken.jp/0010377B6129P2Il18tm1AkiIl18tm1AkiIl18tm1AkiIl18tm1Aki
• decreased circulating interleukin-18 level_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0008636B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• increased IgG2c level_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0008896B6129S5Pycardtm1FlvPycardtm1FlvPycardtm1FlvPycardtm1Flv
• increased IgG2c level_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0008896B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• enlarged Peyer's patches_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0008136B6129S5Pycardtm1FlvPycardtm1FlvPycardtm1FlvPycardtm1Flv
• increased susceptibility to induced colitis_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0008537B6129S5Pycardtm1FlvPycardtm1FlvPycardtm1FlvPycardtm1Flv
• abnormal large intestine crypts of Lieberkuhn morphology_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0004842B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• increased susceptibility to induced colitis_Casp1<tm1Flv>/Casp1<tm1Flv>,Casp4<del>/Casp4<del>
  http://metadb.riken.jp/0008537B6129S2Casp1tm1FlvCasp1tm1FlvCasp1tm1FlvCasp4delCasp4delCasp4delCasp1tm1Flv
• increased leukocyte cell number_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0000218B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• increased susceptibility to induced colitis_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0008537B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• increased sensitivity to xenobiotic induced morbidity/mortality_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0009766B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• increased IgA level_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0002495B6129S5Pycardtm1FlvPycardtm1FlvPycardtm1FlvPycardtm1Flv
• abnormal gut flora balance_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0010377B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• decreased susceptibility to induced colitis_Nlrp3<tm1Flv>/Nlrp3<tm1Flv>
  http://metadb.riken.jp/0008539I129S5SvEvBrdNlrp3tm1FlvNlrp3tm1FlvNlrp3tm1Flv
• increased IgA level_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0002495B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• increased susceptibility to induced colitis_Il18<tm1Aki>/Il18<tm1Aki>
  http://metadb.riken.jp/0008537B6129P2Il18tm1AkiIl18tm1AkiIl18tm1AkiIl18tm1Aki
• abnormal large intestine crypts of Lieberkuhn morphology_Pycard<tm1Flv>/Pycard<tm1Flv>
  http://metadb.riken.jp/0004842B6129S5Pycardtm1FlvPycardtm1FlvPycardtm1FlvPycardtm1Flv
• enlarged Peyer's patches_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0008136B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• increased B cell number_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0005014B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv
• decreased interleukin-18 secretion_Nlrp6<tm1Flv>/Nlrp6<tm1Flv>
  http://metadb.riken.jp/0008685B6CgNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1FlvNlrp6tm1Flv