Meng. Xia, et.al., Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20., Immunity, 2013, 39

http://rdf.ncbi.nlm.nih.gov/pubmed/24012418

Meng. Xia, et.al., Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20., Immunity, 2013, 39

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased susceptibility to induced arthritis in RBRC04919
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1007229
• decreased susceptibility to induced arthritis in RBRC05131
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1007712
• decreased susceptibility to induced arthritis in RBRC04918
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1007158

allele

http://purl.org/net/cito/citesAsAuthority

• Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5563008

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating tumor necrosis factor level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008553B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased IgM level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0002494B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased susceptibility to autoimmune disorder_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0005350B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased IgG2a level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008500B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased interleukin-6 secretion_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008705B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• abnormal inflammatory response_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>,Il6<tm1Kopf>/Il6<tm1Kopf>
  http://metadb.riken.jp/0001845B6CgAsh1lTnpbActRFP1AF0180T25ZhuIl6tm1KopfAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuIl6tm1KopfIl6tm1KopfAsh1lTnpbActRFP1AF0180T25ZhuIl6tm1Kopf
• increased susceptibility to induced arthritis_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0003724B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased IgA level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0002495B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased tumor necrosis factor secretion_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008560B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased susceptibility to endotoxin shock_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008735B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased susceptibility to bacterial infection_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0002412B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased susceptibility to bacterial infection induced morbidity/mortality_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0009788B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased susceptibility to induced arthritis_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>,Il6<tm1Kopf>/Il6<tm1Kopf>
  http://metadb.riken.jp/0003724B6CgAsh1lTnpbActRFP1AF0180T25ZhuIl6tm1KopfAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuIl6tm1KopfIl6tm1KopfAsh1lTnpbActRFP1AF0180T25ZhuIl6tm1Kopf
• pulmonary hyperemia_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0010855B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• decreased susceptibility to induced arthritis_Il6<tm1Kopf>/Il6<tm1Kopf>
  http://metadb.riken.jp/0003436B6129S2Il6tm1KopfJIl6tm1KopfIl6tm1KopfIl6tm1Kopf
• increased IgG1 level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008499B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased IgG2b level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008501B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased autoantibody level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0003725B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• glomerulonephritis_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0002743B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu
• increased circulating interleukin-6 level_Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>/Ash1l<Tn(pb-Act-RFP)1.AF0-180T25Zhu>
  http://metadb.riken.jp/0008596B6FVBAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25ZhuAsh1lTnpbActRFP1AF0180T25Zhu