<p>Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, <db_xref db="EC" dbkey="3.3.1.1"/>) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD<sup>+</sup> as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding.</p><p>This entry represents two highly conserved regions. The first pattern is located in the N-terminal section; the second is derived from a glycine-rich region in the central part of S-adenosyl-L-homocysteine hydrolase, a region thought to be involved in NAD-binding. </p>