<p>This entry represents NAD- and NADP-binding domains with a core Rossmann-type fold, which consists of 3-layers alpha/beta/alpha, where the six beta strands are parallel in the order 321456. Many different enzymes contain an NAD/NADP-binding domain, including:</p><p> <ul><li>C-terminal domain of alcohol dehydrogenases [<cite idref="PUB00031657"/>]</li><li>Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) [<cite idref="PUB00000446"/>]</li><li>N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase [<cite idref="PUB00023536"/>]</li><li>NAD-binding domain of formate/glycerate dehydrogenases [<cite idref="PUB00032846"/>]</li><li>N-terminal domain of sirohaem synthase [<cite idref="PUB00029889"/>]</li><li>N-terminal domain of lactate dehydrogenase [<cite idref="PUB00025866"/>]</li><li>N-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands) [<cite idref="PUB00041823"/>]</li><li>C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix [<cite idref="PUB00025375"/>]</li><li>NAD-binding domain of certain potassium channels [<cite idref="PUB00025981"/>]</li><li>C-terminal domain of the transcriptional repressor Rex [<cite idref="PUB00032388"/>]</li><li>Ornithine cyclodeaminase [<cite idref="PUB00031693"/>]</li><li>CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase [<cite idref="PUB00015984"/>]</li></ul> </p>