<p> dTDP-4-dehydrorhamnose reductase (<db_xref db="EC" dbkey="1.1.1.133"/>) catalyzes the last of 4 steps in making dTDP-rhamnose, a precursor of LPS molecules such as core antigen and O-antigen.<reaction> dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH </reaction> </p>