CD02710

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02710

CD02710

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Abl1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• c-abl oncogene 1, non-receptor tyrosine kinase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• tyrosine-protein kinase ABL1
• c-abl oncogene 1, receptor tyrosine kinase
• proto-oncogene tyrosine-protein kinase ABL1
• v-abl Abelson murine leukemia oncogene 1
• p150
• Abelson murine leukemia oncogene
• Abelson tyrosine-protein kinase 1
• c-abl oncogene 1, non-receptor tyrosine kinase
• abelson murine leukemia viral oncogene homolog 1
• proto-oncogene c-Abl

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• E430008G22Rik
• c-Abl
• Abl
• AI325092

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/11350

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• c-abl oncogene 1, non-receptor tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:87859

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001112703
• https://www.ncbi.nlm.nih.gov/nuccore/NM_009594

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000026842;%20ENSMUSG00000090901

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.474779
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.1318

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=189980

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Anna. Innocenzi, et.al., An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis., EMBO reports, 2011, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/21212806
• M C. Fulchignoni-Lataud, et.al., Assignment of the rat genes coding for alpha 1-antitrypsin (PI), phosphoenolpyruvate carboxykinase (PEPCK), alcohol dehydrogenase (ADH), and fructose-1,6-bisphosphatase (FDP)., Mammalian genome : official journal of the International Mammalian Genome Society, 1992, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/1316195
• L D. Siracusa, et.al., Identification and applications of repetitive probes for gene mapping in the mouse., Genetics, 1991, 127
  http://rdf.ncbi.nlm.nih.gov/pubmed/1673105
• Zhaozhu. Qiu, et.al., Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20980600
• A. Pilz, et.al., Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2., Genomics, 1992, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/1315305
• D. Barilá, et.al., An intramolecular SH3-domain interaction regulates c-Abl activity., Nature genetics, 1998, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/9500553
• David L. Waning, et.al., c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation., The Journal of biological chemistry, 2011, 286
  http://rdf.ncbi.nlm.nih.gov/pubmed/21081495
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Pameeka S. Smith-Pearson, et.al., Abl kinases are required for invadopodia formation and chemokine-induced invasion., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20937825
• K K. Wong, et.al., A role for c-Abl in c-myc regulation., Oncogene, 1995, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/7862448
• Alexander J. Finn, et.al., Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction., Nature neuroscience, 2003, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/12796783
• R. Risser, et.al., Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice., Proceedings of the National Academy of Sciences of the United States of America, 1978, 75
  http://rdf.ncbi.nlm.nih.gov/pubmed/211509
• H R. Gaskins, et.al., Chromosomal localization of the murine stress protein gene encoding glucose-regulated protein 78 (BiP)., Mammalian genome : official journal of the International Mammalian Genome Society, 1992, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/1362103

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• signal transduction in response to DNA damage
  http://purl.obolibrary.org/obo/GO_0042770
• DNA repair
  http://purl.obolibrary.org/obo/GO_0006281
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• magnesium ion binding
  http://purl.obolibrary.org/obo/GO_0000287
• non-membrane spanning protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004715
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• autophagy
  http://purl.obolibrary.org/obo/GO_0006914
• cell adhesion
  http://purl.obolibrary.org/obo/GO_0007155
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• negative regulation of protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0071901
• ruffle
  http://purl.obolibrary.org/obo/GO_0001726
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• cellular response to DNA damage stimulus
  http://purl.obolibrary.org/obo/GO_0006974
• endocytosis
  http://purl.obolibrary.org/obo/GO_0006897
• protein domain specific binding
  http://purl.obolibrary.org/obo/GO_0019904
• regulation of response to DNA damage stimulus
  http://purl.obolibrary.org/obo/GO_2001020
• macroautophagy
  http://purl.obolibrary.org/obo/GO_0016236
• peptidyl-tyrosine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018108
• DNA damage induced protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006975
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• cytoskeleton
  http://purl.obolibrary.org/obo/GO_0005856
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• manganese ion binding
  http://purl.obolibrary.org/obo/GO_0030145
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• proline-rich region binding
  http://purl.obolibrary.org/obo/GO_0070064
• actin cytoskeleton organization
  http://purl.obolibrary.org/obo/GO_0030036
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• SH3 domain binding
  http://purl.obolibrary.org/obo/GO_0017124
• nucleolus
  http://purl.obolibrary.org/obo/GO_0005730
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• positive regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043065
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• positive regulation of oxidoreductase activity
  http://purl.obolibrary.org/obo/GO_0051353
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677
• protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004713
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• mitogen-activated protein kinase binding
  http://purl.obolibrary.org/obo/GO_0051019
• regulation of cell cycle
  http://purl.obolibrary.org/obo/GO_0051726
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• protein C-terminus binding
  http://purl.obolibrary.org/obo/GO_0008022
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04360
• http://www.genome.jp/dbget-bin/www_bget?map05416
• http://www.genome.jp/dbget-bin/www_bget?map04722
• http://www.genome.jp/dbget-bin/www_bget?map05200
• http://www.genome.jp/dbget-bin/www_bget?map04012
• http://www.genome.jp/dbget-bin/www_bget?map05220
• http://www.genome.jp/dbget-bin/www_bget?map04110

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Neurotrophin signaling pathway
• ErbB signaling pathway
• Cell cycle
• Viral myocarditis
• Chronic myeloid leukemia
• Pathways in cancer
• Axon guidance