CD12601

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12601

CD12601

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Bcar1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• breast cancer anti-estrogen resistance 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• p130cas
• v-crk-associated tyrosine kinase substrate
• breast cancer anti-estrogen resistance protein 1
• breast cancer anti-estrogen resistance 1
• CRK-associated substrate

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Crkas
• Cas
• AI385681
• p130 Cas

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/12927

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• breast cancer anti-estrogen resistance 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:108091

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001198839
• https://www.ncbi.nlm.nih.gov/nuccore/NM_009954

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000031955

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.3758

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=602941

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Jinhong. Huang, et.al., The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons., Molecular biology of the cell, 2006, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/16687575
• A. Casamassima, et.al., Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex., The Journal of biological chemistry, 1997, 272
  http://rdf.ncbi.nlm.nih.gov/pubmed/9083073
• Tatsuya. Tazaki, et.al., p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration., Hepatology (Baltimore, Md.), 2010, 52
  http://rdf.ncbi.nlm.nih.gov/pubmed/20623582
• Kohei. Funasaka, et.al., Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing., The FEBS journal, 2010, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/20637038
• I. Nakamura, et.al., Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts., The Journal of biological chemistry, 1998, 273
  http://rdf.ncbi.nlm.nih.gov/pubmed/9556601
• Teiichi. Furuichi, et.al., Systematizing and cloning of genes involved in the cerebellar cortex circuit development., Neurochemical research, 2011, 36
  http://rdf.ncbi.nlm.nih.gov/pubmed/21243430
• Zhaozhu. Qiu, et.al., Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20980600
• Séverine. Roselli, et.al., The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas., Cellular signalling, 2010, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/20603213
• Akira. Sato, et.al., Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum., Neural networks : the official journal of the International Neural Network Society, 2008, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/18603407
• T R. Polte, et.al., Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas., Proceedings of the National Academy of Sciences of the United States of America, 1995, 92
  http://rdf.ncbi.nlm.nih.gov/pubmed/7479864
• J B. Shaffer, et.al., Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant., The Journal of biological chemistry, 1987, 262
  http://rdf.ncbi.nlm.nih.gov/pubmed/3654595
• S H. Lo, et.al., Progressive kidney degeneration in mice lacking tensin., The Journal of cell biology, 1997, 136
  http://rdf.ncbi.nlm.nih.gov/pubmed/9087448
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• focal adhesion
  http://purl.obolibrary.org/obo/GO_0005925
• SH3 domain binding
  http://purl.obolibrary.org/obo/GO_0017124
• protein domain specific binding
  http://purl.obolibrary.org/obo/GO_0019904
• cell migration
  http://purl.obolibrary.org/obo/GO_0016477
• integrin-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0007229
• positive regulation of cell migration
  http://purl.obolibrary.org/obo/GO_0030335
• B cell receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0050853
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• ruffle
  http://purl.obolibrary.org/obo/GO_0001726
• actin filament organization
  http://purl.obolibrary.org/obo/GO_0007015
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• G-protein coupled receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007186
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• cell chemotaxis
  http://purl.obolibrary.org/obo/GO_0060326
• protein phosphatase binding
  http://purl.obolibrary.org/obo/GO_0019903
• epidermal growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007173
• platelet-derived growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0048008
• cell adhesion
  http://purl.obolibrary.org/obo/GO_0007155
• cellular response to hepatocyte growth factor stimulus
  http://purl.obolibrary.org/obo/GO_0035729
• insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008286
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• cell junction
  http://purl.obolibrary.org/obo/GO_0030054
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• actin cytoskeleton organization
  http://purl.obolibrary.org/obo/GO_0030036
• lamellipodium
  http://purl.obolibrary.org/obo/GO_0030027
• hepatocyte growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0048012
• vascular endothelial growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0048010
• antigen receptor-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0050851

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05100
• http://www.genome.jp/dbget-bin/www_bget?map04670
• http://www.genome.jp/dbget-bin/www_bget?map04510
• http://www.genome.jp/dbget-bin/www_bget?map04062
• http://www.genome.jp/dbget-bin/www_bget?map04810

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Chemokine signaling pathway
• Leukocyte transendothelial migration
• Bacterial invasion of epithelial cells
• Regulation of actin cytoskeleton
• Focal adhesion