CD14948

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD14948

CD14948

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Sptlc2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• serine palmitoyltransferase, long chain base subunit 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• LCB2a
• serine palmitoyltransferase, long chain base subunit 2
• LCB 2
• serine palmitoyltransferase 2
• SPT 2
• serine-palmitoyl-CoA transferase 2
• long chain base biosynthesis protein 2a
• long chain base biosynthesis protein 2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• mKIAA0526
• LCB2
• AI173915

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/20773

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• serine palmitoyltransferase, long chain base subunit 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:108074

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011479

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000021036

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.565

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=605713

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• K. Hanada, et.al., A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis., The Journal of biological chemistry, 1997, 272
  http://rdf.ncbi.nlm.nih.gov/pubmed/9405408
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Etsuko. Ohta, et.al., Analysis of development of lesions in mice with serine palmitoyltransferase (SPT) deficiency -Sptlc2 conditional knockout mice-., Experimental animals, 2009, 58
  http://rdf.ncbi.nlm.nih.gov/pubmed/19897935
• You-Hai. Xu, et.al., Multi-system disorders of glycosphingolipid and ganglioside metabolism., Journal of lipid research, 2010, 51
  http://rdf.ncbi.nlm.nih.gov/pubmed/20211931
• E C. Mandon, et.al., Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver., The Journal of biological chemistry, 1992, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/1317856
• B. Weiss, et.al., Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis., European journal of biochemistry, 1997, 249
  http://rdf.ncbi.nlm.nih.gov/pubmed/9363775
• Zhiqiang. Li, et.al., Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels., The Journal of biological chemistry, 2009, 284
  http://rdf.ncbi.nlm.nih.gov/pubmed/19648608
• M M. Nagiec, et.al., Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase., Gene, 1996, 177
  http://rdf.ncbi.nlm.nih.gov/pubmed/8921873
• David J. Pagliarini, et.al., A mitochondrial protein compendium elucidates complex I disease biology., Cell, 2008, 134
  http://rdf.ncbi.nlm.nih.gov/pubmed/18614015
• S M. Kerr, et.al., Analysis of cDNA sequences from mouse testis., Mammalian genome : official journal of the International Mammalian Genome Society, 1994, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/8000140

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• sphingomyelin biosynthetic process
  http://purl.obolibrary.org/obo/GO_0006686
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• transferase activity, transferring nitrogenous groups
  http://purl.obolibrary.org/obo/GO_0016769
• serine C-palmitoyltransferase activity
  http://purl.obolibrary.org/obo/GO_0004758
• transferase activity, transferring acyl groups
  http://purl.obolibrary.org/obo/GO_0016746
• sphingosine biosynthetic process
  http://purl.obolibrary.org/obo/GO_0046512
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• pyridoxal phosphate binding
  http://purl.obolibrary.org/obo/GO_0030170
• ceramide biosynthetic process
  http://purl.obolibrary.org/obo/GO_0046513
• sphinganine biosynthetic process
  http://purl.obolibrary.org/obo/GO_0046511
• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• serine C-palmitoyltransferase complex
  http://purl.obolibrary.org/obo/GO_0017059
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• biosynthetic process
  http://purl.obolibrary.org/obo/GO_0009058
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map00600
• http://www.genome.jp/dbget-bin/www_bget?map01100

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Metabolic pathways
• Sphingolipid metabolism