CD35321

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD35321

CD35321

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Irs2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• insulin receptor substrate 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• insulin receptor substrate 2
• 4PS

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Irs-2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/384783

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• insulin receptor substrate 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109334

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001081212

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000038894

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.407207

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600797

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Maria Jose. Garcia-Barrado, et.al., Differential sensitivity to adrenergic stimulation underlies the sexual dimorphism in the development of diabetes caused by Irs-2 deficiency., Biochemical pharmacology, 2011, 81
  http://rdf.ncbi.nlm.nih.gov/pubmed/20959116
• Shouhong. Xuan, et.al., Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20947509
• D J. Withers, et.al., Disruption of IRS-2 causes type 2 diabetes in mice., Nature, 1998, 391
  http://rdf.ncbi.nlm.nih.gov/pubmed/9495343
• M J. Welham, et.al., Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells., The Journal of biological chemistry, 1997, 272
  http://rdf.ncbi.nlm.nih.gov/pubmed/8995447
• Jia. Zou, et.al., Rheb1 is required for mTORC1 and myelination in postnatal brain development., Developmental cell, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/21238928
• N J. Kerouz, et.al., Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse., The Journal of clinical investigation, 1997, 100
  http://rdf.ncbi.nlm.nih.gov/pubmed/9399964
• X J. Sun, et.al., Role of IRS-2 in insulin and cytokine signalling., Nature, 1995, 377
  http://rdf.ncbi.nlm.nih.gov/pubmed/7675087
• X J. Sun, et.al., The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action., Molecular endocrinology (Baltimore, Md.), 1997, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/9013772
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Yun Chau. Long, et.al., Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways., Molecular and cellular biology, 2011, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/21135130

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• mammary gland development
  http://purl.obolibrary.org/obo/GO_0030879
• phosphatidylinositol 3-kinase binding
  http://purl.obolibrary.org/obo/GO_0043548
• positive regulation of B cell proliferation
  http://purl.obolibrary.org/obo/GO_0030890
• insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0008286
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• signal transducer activity
  http://purl.obolibrary.org/obo/GO_0004871
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• positive regulation of glucose metabolic process
  http://purl.obolibrary.org/obo/GO_0010907
• positive regulation of glucose import
  http://purl.obolibrary.org/obo/GO_0046326
• negative regulation of kinase activity
  http://purl.obolibrary.org/obo/GO_0033673
• response to glucose
  http://purl.obolibrary.org/obo/GO_0009749
• protein domain specific binding
  http://purl.obolibrary.org/obo/GO_0019904
• positive regulation of fatty acid beta-oxidation
  http://purl.obolibrary.org/obo/GO_0032000
• cellular response to insulin stimulus
  http://purl.obolibrary.org/obo/GO_0032869
• positive regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008284
• microsome
  http://purl.obolibrary.org/obo/GO_0005792
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• negative regulation of B cell apoptotic process
  http://purl.obolibrary.org/obo/GO_0002903
• brain development
  http://purl.obolibrary.org/obo/GO_0007420
• positive regulation of glycogen biosynthetic process
  http://purl.obolibrary.org/obo/GO_0045725
• positive regulation of cell migration
  http://purl.obolibrary.org/obo/GO_0030335
• positive regulation of insulin secretion
  http://purl.obolibrary.org/obo/GO_0032024
• positive regulation of mesenchymal cell proliferation
  http://purl.obolibrary.org/obo/GO_0002053
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• negative regulation of plasma membrane long-chain fatty acid transport
  http://purl.obolibrary.org/obo/GO_0010748
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• cell proliferation
  http://purl.obolibrary.org/obo/GO_0008283
• insulin receptor binding
  http://purl.obolibrary.org/obo/GO_0005158
• protein phosphatase binding
  http://purl.obolibrary.org/obo/GO_0019903

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04722
• http://www.genome.jp/dbget-bin/www_bget?map04910
• http://www.genome.jp/dbget-bin/www_bget?map04930
• http://www.genome.jp/dbget-bin/www_bget?map04920
• http://www.genome.jp/dbget-bin/www_bget?map04960

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Insulin signaling pathway
• Aldosterone-regulated sodium reabsorption
• Adipocytokine signaling pathway
• Type II diabetes mellitus
• Neurotrophin signaling pathway