Jia. Zou, et.al., Rheb1 is required for mTORC1 and myelination in postnatal brain development., Developmental cell, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/21238928

Jia. Zou, et.al., Rheb1 is required for mTORC1 and myelination in postnatal brain development., Developmental cell, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD03176
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03176
• CD00054
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00054
• CD02927
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02927
• CD40964
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40964
• CD00473
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00473
• CD00775
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00775
• CD03195
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03195
• CD01426
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD01426
• CD16017
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16017
• CD05992
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05992
• CD10336
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD10336
• CD02728
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02728
• CD15535
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15535
• CD03296
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03296
• CD03531
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03531
• CD04936
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04936
• CD35321
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD35321
• CD09989
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD09989
• CD41689
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD41689
• CD01216
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD01216
• CD02936
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02936
• CD03236
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03236
• CD15347
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15347
• CD38911
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD38911

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4939476
• Rhebl1<tm1.1Pfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4939475
• Rhebl1<tm1Pfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4939474
• Rheb<tm1.1Pfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4939473

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002083IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• thin cerebral cortex_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0006254IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• increased brain size_Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>/Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005238IC57BL6SJLGtROSA26Sortm1CAGRhebPfwGtROSA26Sortm1CAGRhebPfwTgNescre1Kln0GtROSA26Sortm1CAGRhebPfwTgNescre1Kln
• increased oligodendrocyte number_Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>/Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010160IC57BL6SJLGtROSA26Sortm1CAGRhebPfwGtROSA26Sortm1CAGRhebPfwTgNescre1Kln0GtROSA26Sortm1CAGRhebPfwTgNescre1Kln
• embryonic lethality during organogenesis, complete penetrance_Rheb<tm1.1Pfw>/Rheb<tm1.1Pfw>,Rhebl1<tm1.1Pfw>/Rhebl1<tm1.1Pfw>
  http://metadb.riken.jp/0011098IC57BL6Rhebtm11PfwRhebtm11PfwRhebl1tm11PfwRhebl1tm11PfwRhebl1tm11PfwRhebtm11Pfw
• abnormal brain development_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000913IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• decreased brain weight_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002175IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• no abnormal phenotype detected_Rhebl1<tm1.1Pfw>/Rhebl1<tm1.1Pfw>
  http://metadb.riken.jp/0002169IC57BL6Rhebl1tm11PfwRhebl1tm11PfwRhebl1tm11Pfw
• postnatal growth retardation_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001732IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• thickened cerebral cortex_Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>/Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000789IC57BL6SJLGtROSA26Sortm1CAGRhebPfwGtROSA26Sortm1CAGRhebPfwTgNescre1Kln0GtROSA26Sortm1CAGRhebPfwTgNescre1Kln
• decreased oligodendrocyte number_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009808IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• increased brain weight_Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>/Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002176IC57BL6SJLGtROSA26Sortm1CAGRhebPfwGtROSA26Sortm1CAGRhebPfwTgNescre1Kln0GtROSA26Sortm1CAGRhebPfwTgNescre1Kln
• abnormal cerebral cortex morphology_Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>/Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000788IC57BL6SJLGtROSA26Sortm1CAGRhebPfwGtROSA26Sortm1CAGRhebPfwTgNescre1Kln0GtROSA26Sortm1CAGRhebPfwTgNescre1Kln
• embryonic lethality during organogenesis, complete penetrance_Rheb<tm1.1Pfw>/Rheb<tm1.1Pfw>
  http://metadb.riken.jp/0011098IC57BL6Rhebtm11PfwRhebtm11PfwRhebtm11Pfw
• demyelination_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000921IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• abnormal myelin sheath morphology_Rheb<tm1Pfw>/Rheb<tm1Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003871IC57BL6SJLRhebtm1PfwRhebtm1PfwTgNescre1Kln0Rhebtm1PfwTgNescre1Kln
• hypermyelination_Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>/Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010050IC57BL6SJLGtROSA26Sortm1CAGRhebPfwGtROSA26Sortm1CAGRhebPfwTgNescre1Kln0GtROSA26Sortm1CAGRhebPfwTgNescre1Kln
• neuron hypertrophy_Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>/Gt(ROSA)26Sor<tm1(CAG-Rheb*)Pfw>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005603IC57BL6SJLGtROSA26Sortm1CAGRhebPfwGtROSA26Sortm1CAGRhebPfwTgNescre1Kln0GtROSA26Sortm1CAGRhebPfwTgNescre1Kln