CD41689

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD41689

CD41689

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Tsc2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• tuberous sclerosis 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• tuberous sclerosis 2
• tuberous sclerosis 2 protein homolog

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Tcs2
• tuberin

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/22084

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• tuberous sclerosis 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:102548

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011647
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001039363

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000002496

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.30435

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=191092

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Yinfei. Tan, et.al., Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development., Genesis (New York, N.Y. : 2000), 2010, 48
  http://rdf.ncbi.nlm.nih.gov/pubmed/20665729
• A. Pilz, et.al., The mouse homologue of the human tuberous sclerosis 2 (TSC2) gene maps to chromosome 17, but does not fall within the tw18 or th20 deletions., Genomics, 1995, 26
  http://rdf.ncbi.nlm.nih.gov/pubmed/7601476
• K K. Kim, et.al., Cloning, developmental expression, and evidence for alternative splicing of the murine tuberous sclerosis (TSC2) gene product., Cellular & molecular biology research, 1995, 41
  http://rdf.ncbi.nlm.nih.gov/pubmed/8777431
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Ling-Hui. Zeng, et.al., Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex., Human molecular genetics, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/21062901
• Jia. Zou, et.al., Rheb1 is required for mTORC1 and myelination in postnatal brain development., Developmental cell, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/21238928
• P G. Olsson, et.al., The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene., Genomics, 1996, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/8661056
• L. Xu, et.al., Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues., Genomics, 1995, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/7558029
• Elizabeth A. Barnes, et.al., Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition., The American journal of pathology, 2010, 177
  http://rdf.ncbi.nlm.nih.gov/pubmed/20813961
• P G. Olsson, et.al., The mouse homologue of the tuberin gene (TSC2) maps to a conserved synteny group between mouse chromosome 17 and human 16p13.3., Genomics, 1995, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/7774953

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• positive regulation of GTPase activity
  http://purl.obolibrary.org/obo/GO_0043547
• negative regulation of MAP kinase activity
  http://purl.obolibrary.org/obo/GO_0043407
• negative regulation of protein kinase activity
  http://purl.obolibrary.org/obo/GO_0006469
• negative regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008285
• protein homooligomerization
  http://purl.obolibrary.org/obo/GO_0051260
• negative regulation of TOR signaling
  http://purl.obolibrary.org/obo/GO_0032007
• protein import into nucleus
  http://purl.obolibrary.org/obo/GO_0006606
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• protein kinase B signaling
  http://purl.obolibrary.org/obo/GO_0043491
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• microsome
  http://purl.obolibrary.org/obo/GO_0005792
• protein localization
  http://purl.obolibrary.org/obo/GO_0008104
• cell projection organization
  http://purl.obolibrary.org/obo/GO_0030030
• dendrite
  http://purl.obolibrary.org/obo/GO_0030425
• positive chemotaxis
  http://purl.obolibrary.org/obo/GO_0050918
• neuron projection
  http://purl.obolibrary.org/obo/GO_0043005
• TSC1-TSC2 complex
  http://purl.obolibrary.org/obo/GO_0033596
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• negative regulation of protein kinase B signaling
  http://purl.obolibrary.org/obo/GO_0051898
• protein heterooligomerization
  http://purl.obolibrary.org/obo/GO_0051291
• negative regulation of phosphatidylinositol 3-kinase signaling
  http://purl.obolibrary.org/obo/GO_0014067
• establishment of protein localization
  http://purl.obolibrary.org/obo/GO_0045184
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• GTPase activator activity
  http://purl.obolibrary.org/obo/GO_0005096
• regulation of cell cycle
  http://purl.obolibrary.org/obo/GO_0051726
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• caveola
  http://purl.obolibrary.org/obo/GO_0005901
• neural tube closure
  http://purl.obolibrary.org/obo/GO_0001843
• growth cone
  http://purl.obolibrary.org/obo/GO_0030426
• response to hypoxia
  http://purl.obolibrary.org/obo/GO_0001666
• cytoskeletal part
  http://purl.obolibrary.org/obo/GO_0044430
• acute-phase response
  http://purl.obolibrary.org/obo/GO_0006953
• 14-3-3 protein binding
  http://purl.obolibrary.org/obo/GO_0071889
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• insulin-like growth factor receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0048009
• protein homodimerization activity
  http://purl.obolibrary.org/obo/GO_0042803
• membrane raft
  http://purl.obolibrary.org/obo/GO_0045121
• phosphatidylinositol 3-kinase signaling
  http://purl.obolibrary.org/obo/GO_0014065
• heart development
  http://purl.obolibrary.org/obo/GO_0007507
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• regulation of insulin receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0046626
• negative regulation of cell size
  http://purl.obolibrary.org/obo/GO_0045792
• regulation of endocytosis
  http://purl.obolibrary.org/obo/GO_0030100
• phosphatase binding
  http://purl.obolibrary.org/obo/GO_0019902
• negative regulation of epithelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0050680
• negative regulation of Wnt signaling pathway
  http://purl.obolibrary.org/obo/GO_0030178

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04910
• http://www.genome.jp/dbget-bin/www_bget?map04115
• http://www.genome.jp/dbget-bin/www_bget?map04150

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• p53 signaling pathway
• Insulin signaling pathway
• mTOR signaling pathway