Harald. Mikkers, et.al., Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors., Molecular and cellular biology, 2004, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/15199164

Harald. Mikkers, et.al., Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors., Molecular and cellular biology, 2004, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD10228
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD10228

allele

http://purl.org/net/cito/citesAsAuthority

• Pim3<tm1Brn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3050663
• Pim2<tm1Brn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3050662

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased B cell proliferation_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0005093I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• decreased mean corpuscular volume_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0002591I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• decreased pre-B cell number_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0008209I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• decreased megakaryocyte cell number_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0008255I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• decreased T cell proliferation_Pim2<tm1Brn>/Pim2<tm1Brn>
  http://metadb.riken.jp/0005095I129POlaFVBNPim2tm1BrnPim2tm1BrnPim2tm1Brn
• decreased T cell proliferation_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0005095I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• increased early pro-B cell number_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0003133I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• abnormal proerythroblast morphology_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0002416I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• postnatal growth retardation_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0001732I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• decreased pro-B cell number_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0008208I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• increased erythrocyte cell number_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0003131I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• decreased B cell number_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0005017I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn
• no abnormal phenotype detected_Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0002169I129POlaFVBNPim3tm1BrnPim3tm1BrnPim3tm1Brn
• decreased birth body size_Pim1<tm1Pwl>/Pim1<tm1Pwl>,Pim2<tm1Brn>/Pim2<tm1Brn>,Pim3<tm1Brn>/Pim3<tm1Brn>
  http://metadb.riken.jp/0009703I129POlaFVBNPim1tm1PwlPim1tm1PwlPim2tm1BrnPim2tm1BrnPim3tm1BrnPim3tm1BrnPim3tm1BrnPim1tm1PwlPim2tm1Brn