Ari. Waisman, et.al., IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta., The Journal of experimental medicine, 2007, 204

http://rdf.ncbi.nlm.nih.gov/pubmed/17420268

Ari. Waisman, et.al., IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta., The Journal of experimental medicine, 2007, 204

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD16043
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16043

allele

http://purl.org/net/cito/citesAsAuthority

• Igh<tm1.2Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3760662
• Igh<tm1.1Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3760655

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased pre-B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>
  http://metadb.riken.jp/0008209I129C57BL6Cd79atm51CgnCd79atm51CgnCd79atm51Cgn
• abnormal B cell morphology_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0004939BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• decreased marginal zone B cell number_Cd22<tm1Lam>/Cd22<tm1Lam>
  http://metadb.riken.jp/0008182I129C57BL6Cd22tm1LamCd22tm1LamCd22tm1Lam
• decreased B-1a cell number_Cd22<tm1Lam>/Cd22<tm1Lam>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008168I129BALBcC57BL6Cd22tm1LamCd22tm1LamIghtm12RskyIghtm12RskyIghtm12RskyCd22tm1Lam
• increased marginal zone B cell number_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008181BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• decreased mature B cell number_Cd22<tm1Lam>/Cd22<tm1Lam>
  http://metadb.riken.jp/0008211I129C57BL6Cd22tm1LamCd22tm1LamCd22tm1Lam
• decreased transitional stage B cell number_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008190BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• decreased B-1a cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>
  http://metadb.riken.jp/0008168I129C57BL6Cd79atm51CgnCd79atm51CgnCd79atm51Cgn
• abnormal class switch recombination_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>,Tg(CD19-cre/ERT2)1Cgn/?
  http://metadb.riken.jp/0004816IBALBcIghtm12RskyIghtm12RskyTgCD19creERT21CgnIghtm12RskyTgCD19creERT21Cgn
• decreased mature B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008211I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky
• decreased pre-B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008209I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky
• decreased T cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>
  http://metadb.riken.jp/0005018I129C57BL6Cd79atm51CgnCd79atm51CgnCd79atm51Cgn
• abnormal class switch recombination_Cd79a<tm5.1Cgn>/Cd79a<+>,Igh<tm1.2Rsky>/Igh<+>
  http://metadb.riken.jp/0004816I129BALBcC57BL6Cd79atm51CgnCd79aIghtm12RskyIghCd79aIghtm12RskyIghCd79atm51Cgn
• abnormal class switch recombination_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<+>
  http://metadb.riken.jp/0004816I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghIghCd79atm51CgnIghtm12Rsky
• abnormal pro-B cell differentiation_Cd79a<tm4.1Cgn>/Cd79a<tm4.1Cgn>,Igh<tm1.2Rsky>/Igh<+>
  http://metadb.riken.jp/0008233IBALBcC57BL6Cd79atm41CgnCd79atm41CgnIghtm12RskyIghCd79atm41CgnIghIghtm12Rsky
• decreased IgM level_Igh<tm1.1Rsky>/Igh<tm1.1Rsky>
  http://metadb.riken.jp/0001806BALBcIghtm11RskyIghtm11RskyIghtm11RskyIghtm11Rsky
• abnormal class switch recombination_Cd22<tm1Lam>/Cd22<tm1Lam>,Igh<tm1.2Rsky>/Igh<+>
  http://metadb.riken.jp/0004816I129BALBcC57BL6Cd22tm1LamCd22tm1LamIghtm12RskyIghIghIghtm12RskyCd22tm1Lam
• decreased IgE level_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0002492BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• abnormal B cell morphology_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0004939I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky
• abnormal B cell activation_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>,Tg(CD19-cre/ERT2)1Cgn/?
  http://metadb.riken.jp/0008217IBALBcIghtm12RskyIghtm12RskyTgCD19creERT21CgnIghtm12RskyTgCD19creERT21Cgn
• abnormal mature B cell morphology_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008171BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• increased B-1b cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008169I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky
• decreased immature B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>
  http://metadb.riken.jp/0008215I129C57BL6Cd79atm51CgnCd79atm51CgnCd79atm51Cgn
• decreased T cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0005018I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky
• abnormal B cell activation_Cd22<tm1Lam>/Cd22<tm1Lam>
  http://metadb.riken.jp/0008217I129C57BL6Cd22tm1LamCd22tm1LamCd22tm1Lam
• decreased pre-B cell number_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008209BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• increased pro-B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>
  http://metadb.riken.jp/0008186I129C57BL6Cd79atm51CgnCd79atm51CgnCd79atm51Cgn
• decreased immunoglobulin level_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0002460BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• abnormal B cell activation_Cd22<tm1Lam>/Cd22<tm1Lam>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008217I129BALBcC57BL6Cd22tm1LamCd22tm1LamIghtm12RskyIghtm12RskyIghtm12RskyCd22tm1Lam
• decreased IgA level_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0001807BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• increased pro-B cell number_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008186BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• decreased immature B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008215I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky
• decreased mature B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>
  http://metadb.riken.jp/0008211I129C57BL6Cd79atm51CgnCd79atm51CgnCd79atm51Cgn
• abnormal class switch recombination_Igh<tm1.1Rsky>/Igh<tm1.1Rsky>
  http://metadb.riken.jp/0004816BALBcIghtm11RskyIghtm11RskyIghtm11RskyIghtm11Rsky
• decreased IgM level_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0001806BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• decreased mature B cell number_Igh<tm1.2Rsky>/Igh<+>,Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0008211IBALBcC57BL6Ightm12RskyIghTnfrsf13ctm1MassTnfrsf13ctm1MassTnfrsf13ctm1MassIghtm12RskyIgh
• abnormal B cell morphology_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>
  http://metadb.riken.jp/0004939I129C57BL6Cd79atm51CgnCd79atm51CgnCd79atm51Cgn
• increased IgG1 level_Igh<tm1.2Rsky>/Igh<+>
  http://metadb.riken.jp/0008499BALBcIghtm12RskyIghtm12RskyIghIghIghtm12Rsky
• decreased IgD level_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0002491BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• abnormal B cell activation_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008217BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• decreased B-1a cell number_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008168BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• abnormal B cell proliferation_Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0005153BALBcIghtm12RskyIghtm12RskyIghtm12RskyIghtm12Rsky
• abnormal class switch recombination_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0004816I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky
• increased pro-B cell number_Cd79a<tm5.1Cgn>/Cd79a<tm5.1Cgn>,Igh<tm1.2Rsky>/Igh<tm1.2Rsky>
  http://metadb.riken.jp/0008186I129BALBcC57BL6Cd79atm51CgnCd79atm51CgnIghtm12RskyIghtm12RskyCd79atm51CgnIghtm12Rsky