Masatsugu. Oh-Hora, et.al., Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance., Nature immunology, 2008, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/18327260

Masatsugu. Oh-Hora, et.al., Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance., Nature immunology, 2008, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD27924
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD27924

allele

http://purl.org/net/cito/citesAsAuthority

• Stim1<tm1Rao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3778911
• Stim1<tm1.1Rao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3778912
• Stim2<tm1Rao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3778913
• Stim2<tm1.1Rao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3778914

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased interleukin-2 secretion_Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008688IC57BL6DBA2SJLStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0TgCd4cre1CwiStim2tm1Rao
• decreased interleukin-4 secretion_Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008700IC57BL6DBA2SJLStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0TgCd4cre1CwiStim2tm1Rao
• decreased interleukin-2 secretion_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008688IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• postnatal lethality, complete penetrance_Stim1<tm1.1Rao>/Stim1<tm1.1Rao>
  http://metadb.riken.jp/0011085IBALBcJC57BL6SJLStim1tm11RaoStim1tm11RaoStim1tm11Rao
• decreased regulatory T cell number_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004974IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal CD4-positive, alpha-beta T cell physiology_Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005463IC57BL6DBA2SJLStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0TgCd4cre1CwiStim2tm1Rao
• perinatal lethality, incomplete penetrance_Stim1<tm1.1Rao>/Stim1<tm1.1Rao>
  http://metadb.riken.jp/0011090IBALBcJC57BL6SJLStim1tm11RaoStim1tm11RaoStim1tm11Rao
• increased IgG1 level_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008499IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal cell physiology_Stim1<tm1.1Rao>/Stim1<tm1.1Rao>
  http://metadb.riken.jp/0005621IBALBcJC57BL6SJLStim1tm11RaoStim1tm11RaoStim1tm11Rao
• abnormal granulocyte morphology_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002441IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• decreased interleukin-2 secretion_Stim1<tm1Rao>/Stim1<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008688IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1Cwi
• abnormal B cell differentiation_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002144IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• enlarged lymph nodes_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000702IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal immune system physiology_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001790IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal T-helper 2 physiology_Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005466IC57BL6DBA2SJLStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0TgCd4cre1CwiStim2tm1Rao
• postnatal growth retardation_Stim2<tm1.1Rao>/Stim2<tm1.1Rao>
  http://metadb.riken.jp/0001732IBALBcJC57BL6SJLStim2tm11RaoStim2tm11RaoStim2tm11Rao
• blepharitis_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005251IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal CD4-positive, alpha-beta T cell physiology_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005463IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• perinatal lethality, incomplete penetrance_Stim1<tm1.1Rao>/Stim1<tm1.1Rao>
  http://metadb.riken.jp/0011090IBALBcJC57BL6ICRSJLStim1tm11RaoStim1tm11RaoStim1tm11Rao
• postnatal lethality, complete penetrance_Stim1<tm1.1Rao>/Stim1<tm1.1Rao>
  http://metadb.riken.jp/0011085IBALBcJC57BL6ICRSJLStim1tm11RaoStim1tm11RaoStim1tm11Rao
• decreased T cell proliferation_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005095IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• decreased interferon-gamma secretion_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008567IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal T-helper 1 physiology_Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005465IC57BL6DBA2SJLStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0TgCd4cre1CwiStim2tm1Rao
• decreased interferon-gamma secretion_Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008567IC57BL6DBA2SJLStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0TgCd4cre1CwiStim2tm1Rao
• enlarged spleen_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000691IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• increased spleen germinal center number_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008481IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• increased germinal center B cell number_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008177IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• dermatitis_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001194IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• premature death_Stim2<tm1.1Rao>/Stim2<tm1.1Rao>
  http://metadb.riken.jp/0002083IBALBcJC57BL6SJLStim2tm11RaoStim2tm11RaoStim2tm11Rao
• increased lymphocyte cell number_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005013IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal immune system morphology_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000685IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• abnormal cell physiology_Stim2<tm1.1Rao>/Stim2<tm1.1Rao>
  http://metadb.riken.jp/0005621IBALBcJC57BL6SJLStim2tm11RaoStim2tm11RaoStim2tm11Rao
• abnormal CD4-positive, alpha-beta T cell physiology_Stim1<tm1Rao>/Stim1<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005463IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1Cwi
• increased lymphocyte cell number_Stim1<tm1Rao>/Stim1<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005013IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1Cwi
• abnormal lymph organ size_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002221IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao
• postnatal growth retardation_Stim1<tm1.1Rao>/Stim1<tm1.1Rao>
  http://metadb.riken.jp/0001732IBALBcJC57BL6ICRSJLStim1tm11RaoStim1tm11RaoStim1tm11Rao
• abnormal T cell differentiation_Stim1<tm1Rao>/Stim1<tm1Rao>,Stim2<tm1Rao>/Stim2<tm1Rao>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0002145IC57BL6DBA2SJLStim1tm1RaoStim1tm1RaoStim2tm1RaoStim2tm1RaoTgCd4cre1Cwi0Stim1tm1RaoTgCd4cre1CwiStim2tm1Rao