Benjamin. Kleaveland, et.al., Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway., Nature medicine, 2009, 15

http://rdf.ncbi.nlm.nih.gov/pubmed/19151727

Benjamin. Kleaveland, et.al., Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway., Nature medicine, 2009, 15

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD31736
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD31736

allele

http://purl.org/net/cito/citesAsAuthority

• Heg1<tm1Mlkn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3838392

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• postnatal lethality, incomplete penetrance_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0011086EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• lethality throughout fetal growth and development, incomplete penetrance_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0011109EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• abnormal heart atrium morphology_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0003105EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• pericardial edema_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0001787I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• abnormal vasculogenesis_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0001622I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• pericardial edema_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0001787I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• embryonic lethality during organogenesis, complete penetrance_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0011098I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• abnormal cardinal vein morphology_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0004783I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• embryonic lethality during organogenesis, incomplete penetrance_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0011108EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• abnormal vasculogenesis_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0001622I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• abnormal dorsal aorta morphology_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0004787I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• lung hemorrhage_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0001182EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• abnormal lymph circulation_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0003659EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• embryonic lethality during organogenesis, complete penetrance_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0011098I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• abnormal vascular endothelial cell development_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0003542I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• dilated aortic sac_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0012511I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• dilated aortic sac_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0012511I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• abnormal lymphatic vessel endothelium morphology_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0010195EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• abnormal cardinal vein morphology_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0004783I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• hemopericardium_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0005244I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• chylous ascites_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0012080EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• embryonic growth retardation_Ccm2<Gt(RRG051)Byg>/Ccm2<Gt(RRG051)Byg>
  http://metadb.riken.jp/0003984I129P2OlaHsdCcm2GtRRG051BygCcm2GtRRG051BygCcm2GtRRG051Byg
• abnormal vascular endothelial cell development_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0003542I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• embryonic growth retardation_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0003984I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• hemopericardium_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0005244I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• lymphangiectasis_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0004038EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• hemopericardium_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0005244EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• abnormal dorsal aorta morphology_Ccm2<Gt(RRG051)Byg>/Ccm2<+>,Heg1<tm1Mlkn>/Heg1<+>
  http://metadb.riken.jp/0004787I129Sv129P2OlaHsdC57BL6Ccm2GtRRG051BygCcm2Heg1tm1MlknHeg1Heg1tm1MlknHeg1Ccm2Ccm2GtRRG051Byg
• ventricular septal defect_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0010402EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn
• abnormal heart development_Heg1<tm1Mlkn>/Heg1<tm1Mlkn>
  http://metadb.riken.jp/0000267EB6129Heg1tm1MlknorI129SvC57BL6Heg1tm1MlknHeg1tm1MlknHeg1tm1Mlkn