Jung Min. Kim, et.al., Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype., Developmental cell, 2009, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/19217432

Jung Min. Kim, et.al., Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype., Developmental cell, 2009, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00085
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00085

allele

http://purl.org/net/cito/citesAsAuthority

• Usp1<tm1.1Ada>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3838373
• Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3530554

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body weight_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0001262I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• oligozoospermia_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0002687C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• oligozoospermia_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0002687I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• male infertility_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001925C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• increased adenoma incidence_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0010383I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• fetal growth retardation_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0004201I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• increased mortality induced by gamma-irradiation_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001658C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• perinatal lethality, incomplete penetrance_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0011090I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• microphthalmia_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0001297I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• small testis_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0001147I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• seminiferous tubule degeneration_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001154C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• postnatal growth retardation_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0001732I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• increased carcinoma incidence_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0002038I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• decreased bone marrow cell number_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0000333C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• abnormal spermatocyte morphology_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0006379C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• cyanosis_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001575C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• abnormal spermatid morphology_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0006380C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• abnormal spermatogonia morphology_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0006378C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• decreased body weight_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001262C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• reduced female fertility_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001923C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• small testis_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001147C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• abnormal male meiosis_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0005169I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• induced chromosome breakage_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>,Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0004030I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexUsp1tm11AdaUsp1tm11AdaFancd2GtOST57859LexUsp1tm11Ada
• induced chromosome breakage_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0004030C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• edema_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0001785C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• ovary atrophy_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>,Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0004833I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexUsp1tm11AdaUsp1tm11AdaFancd2GtOST57859LexUsp1tm11Ada
• decreased oocyte number_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0005431C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• abnormal seminiferous tubule morphology_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0002216I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• abnormal spermatocyte morphology_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0006379I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• decreased mature ovarian follicle number_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>
  http://metadb.riken.jp/0002682I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexFancd2GtOST57859Lex
• increased cellular sensitivity to ionizing radiation_Fancd2<Gt(OST57859)Lex>/Fancd2<Gt(OST57859)Lex>,Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0004227I129S5SvEvBrdC57BL6Fancd2GtOST57859LexFancd2GtOST57859LexUsp1tm11AdaUsp1tm11AdaFancd2GtOST57859LexUsp1tm11Ada
• postnatal lethality, incomplete penetrance_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0011086C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada
• abnormal male germ cell morphology_Usp1<tm1.1Ada>/Usp1<tm1.1Ada>
  http://metadb.riken.jp/0006362C57BL6Usp1tm11AdaUsp1tm11AdaUsp1tm11AdaUsp1tm11Ada