Paula. Martínez, et.al., Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice., Genes & development, 2009, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/19679647

Paula. Martínez, et.al., Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice., Genes & development, 2009, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD16458
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16458

allele

http://purl.org/net/cito/citesAsAuthority

• Terf1<tm1.1Blas>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4357772

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• absent hair follicles_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000378I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• oral leukoplakia_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003751I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Trp53tm1TyjTrp53tm1TyjTerf1tm11BlasTgKRT5cre1TakTrp53tm1Tyj
• hyperpigmentation_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001188I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• perinatal lethality, incomplete penetrance_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0011090I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• decreased cell proliferation_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>
  http://metadb.riken.jp/0000352I129S1Sv129X1SvJC57BL6SJLTerf1tm11BlasTerf1tm11BlasTerf1tm11Blas
• abnormal tongue epithelium morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000764I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• hyperkeratosis_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001242I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal nail morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0000579I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Trp53tm1TyjTrp53tm1TyjTerf1tm11BlasTgKRT5cre1TakTrp53tm1Tyj
• decreased body weight_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001262I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal telomere length_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0003155I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal palate morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0003755I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal chromosome morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0003702I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal telomere length_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>
  http://metadb.riken.jp/0003155I129S1Sv129X1SvJC57BL6SJLTerf1tm11BlasTerf1tm11BlasTerf1tm11Blas
• abnormal esophageal epithelium morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000468I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• increased skin squamous cell carcinoma incidence_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0009704I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Trp53tm1TyjTrp53tm1TyjTerf1tm11BlasTgKRT5cre1TakTrp53tm1Tyj
• postnatal growth retardation_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001732I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• early cellular replicative senescence_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>
  http://metadb.riken.jp/0008008I129S1Sv129X1SvJC57BL6SJLTerf1tm11BlasTerf1tm11BlasTerf1tm11Blas
• abnormal stomach epithelium morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000471I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal chromosome morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>
  http://metadb.riken.jp/0003702I129S1Sv129X1SvJC57BL6SJLTerf1tm11BlasTerf1tm11BlasTerf1tm11Blas
• abnormal skin physiology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0005501I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• absent sebaceous gland_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000648I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal skin development_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0003941I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• skin inflammation_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0004947I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• epidermal hyperplasia_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001222I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal filiform papillae morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000763I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal keratinocyte physiology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0003453I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• orthokeratosis_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0009675I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal esophagus morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0000467I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• abnormal skin morphology_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0002060I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak
• impaired skin barrier function_Terf1<tm1.1Blas>/Terf1<tm1.1Blas>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0002796I129C3HC57BL6SJLTerf1tm11BlasTerf1tm11BlasTgKRT5cre1Tak0Terf1tm11BlasTgKRT5cre1Tak