Tatsuya. Yoshizawa, et.al., The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts., The Journal of clinical investigation, 2009, 119

http://rdf.ncbi.nlm.nih.gov/pubmed/19726872

Tatsuya. Yoshizawa, et.al., The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts., The Journal of clinical investigation, 2009, 119

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD40275
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40275

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(CMV-Atf4)1Kry
  http://metadb.riken.jp/db/mgi_rdf/MGI:4360489
• Atf4<tm1Kry>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4360484

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased physiological sensitivity to xenobiotic_Tg(Col1a1-Atf4)1Kry/0
  http://metadb.riken.jp/0008873IFVBTgCol1a1Atf41Kry0TgCol1a1Atf41Kry
• abnormal circulating glucose level_Tg(Col1a1-Atf4)1Kry/0
  http://metadb.riken.jp/0000188IFVBTgCol1a1Atf41Kry0TgCol1a1Atf41Kry
• increased circulating insulin level_Atf4<tm1Tow>/Atf4<+>,Ptprv<tm1Asmi>/Ptprv<+>
  http://metadb.riken.jp/0002079EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4Ptprvtm1AsmiPtprvPtprvAtf4Atf4tm1TowPtprvtm1Asmi
• abnormal glycogen homeostasis_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0005438IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• increased circulating insulin level_Ptprv<tm1Asmi>/Ptprv<tm1Asmi>
  http://metadb.riken.jp/0002079I129P2OlaHsdC57BL6JPtprvtm1AsmiPtprvtm1AsmiPtprvtm1Asmi
• decreased insulin secretion_Tg(Col1a1-Atf4)1Kry/0
  http://metadb.riken.jp/0003059IFVBTgCol1a1Atf41Kry0TgCol1a1Atf41Kry
• decreased circulating glucose level_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0005560EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• increased insulin secretion_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0003058EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• increased pancreatic beta cell mass_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0009113EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• increased circulating glucose level_Tg(Col1a1-Atf4)1Kry/0
  http://metadb.riken.jp/0005559IFVBTgCol1a1Atf41Kry0TgCol1a1Atf41Kry
• improved glucose tolerance_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0005292IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• decreased total fat pad weight_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0008907EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• increased insulin secretion_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0003058IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• increased pancreatic beta cell proliferation_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0011819EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• improved glucose tolerance_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0005292EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• decreased pancreatic beta cell proliferation_Tg(Col1a1-Atf4)1Kry/0
  http://metadb.riken.jp/0011820IFVBTgCol1a1Atf41Kry0TgCol1a1Atf41Kry
• abnormal gluconeogenesis_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0003383EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• increased circulating insulin level_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0002079EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• increased pancreatic beta cell proliferation_Ptprv<tm1Asmi>/Ptprv<tm1Asmi>
  http://metadb.riken.jp/0011819I129P2OlaHsdC57BL6JPtprvtm1AsmiPtprvtm1AsmiPtprvtm1Asmi
• abnormal gluconeogenesis_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0003383IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• decreased circulating insulin level_Tg(Col1a1-Atf4)1Kry/0
  http://metadb.riken.jp/0002727IFVBTgCol1a1Atf41Kry0TgCol1a1Atf41Kry
• abnormal glucose homeostasis_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0002078IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• decreased circulating glucose level_Atf4<tm1Tow>/Atf4<+>,Ptprv<tm1Asmi>/Ptprv<+>
  http://metadb.riken.jp/0005560EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4Ptprvtm1AsmiPtprvPtprvAtf4Atf4tm1TowPtprvtm1Asmi
• decreased circulating glucose level_Ptprv<tm1Asmi>/Ptprv<tm1Asmi>
  http://metadb.riken.jp/0005560I129P2OlaHsdC57BL6JPtprvtm1AsmiPtprvtm1AsmiPtprvtm1Asmi
• increased insulin sensitivity_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0002891IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• increased insulin sensitivity_Atf4<tm1Tow>/Atf4<tm1Tow>
  http://metadb.riken.jp/0002891EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4tm1TowAtf4tm1Tow
• increased pancreatic beta cell proliferation_Atf4<tm1Tow>/Atf4<+>,Ptprv<tm1Asmi>/Ptprv<+>
  http://metadb.riken.jp/0011819EI129P2OlaHsd129S1Sv129X1SvJC57BL6JNIHBlackSwissorI129P2OlaHsdC57BL6JNIHBlackSwissAtf4tm1TowAtf4Ptprvtm1AsmiPtprvPtprvAtf4Atf4tm1TowPtprvtm1Asmi
• decreased circulating glucose level_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0005560IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• decreased body weight_Atf4<tm1Kry>/Atf4<tm1Kry>,Tg(Col1a1-cre)1Kry/0
  http://metadb.riken.jp/0001262IC57BL6JFVBAtf4tm1KryAtf4tm1KryTgCol1a1cre1Kry0TgCol1a1cre1KryAtf4tm1Kry
• impaired glucose tolerance_Tg(Col1a1-Atf4)1Kry/0
  http://metadb.riken.jp/0005293IFVBTgCol1a1Atf41Kry0TgCol1a1Atf41Kry