Kristy. Iskandar, et.al., PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake., American journal of physiology. Endocrinology and metabolism, 2010, 298

http://rdf.ncbi.nlm.nih.gov/pubmed/20103739

Kristy. Iskandar, et.al., PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake., American journal of physiology. Endocrinology and metabolism, 2010, 298

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD18914
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18914

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm2(Foxo1)Jnk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4820847
• Gt(ROSA)26Sor<tm1(Foxo1)Jnk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4820846

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased total body fat amount_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0010024I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• abnormal homeostasis_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001764I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• abnormal neuron physiology_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0004811I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• increased corticotroph apoptosis_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0013347I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• increased insulin sensitivity_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002891I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• increased body weight_Gt(ROSA)26Sor<tm1(Foxo1)Jnk>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001260I129S4SvJaeC57BL6DBA2FVBNGtROSA26Sortm1Foxo1JnkGtROSA26SorPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0TgPomc1cre16LowlTgCAGcatlacZ11MiyaGtROSA26SorGtROSA26Sortm1Foxo1JnkPdpk1tm1Maka
• decreased circulating corticosterone level_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002665I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• abnormal pituitary intermediate lobe morphology_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0008130I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• increased pituitary gland apoptosis_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0013344I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• increased melanotroph apoptosis_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0013346I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• increased food intake_Gt(ROSA)26Sor<tm2(Foxo1)Jnk>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0011939I129S4SvJaeC57BL6DBA2FVBNGtROSA26Sortm2Foxo1JnkGtROSA26SorPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaGtROSA26Sortm2Foxo1JnkGtROSA26SorTgCAGcatlacZ11MiyaTgPomc1cre16Lowl
• increased food intake_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0011939I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya
• increased total body fat amount_Gt(ROSA)26Sor<tm2(Foxo1)Jnk>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0010024I129S4SvJaeC57BL6DBA2FVBNGtROSA26Sortm2Foxo1JnkGtROSA26SorPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaGtROSA26Sortm2Foxo1JnkGtROSA26SorTgCAGcatlacZ11MiyaTgPomc1cre16Lowl
• increased body weight_Gt(ROSA)26Sor<tm2(Foxo1)Jnk>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001260I129S4SvJaeC57BL6DBA2FVBNGtROSA26Sortm2Foxo1JnkGtROSA26SorPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaGtROSA26Sortm2Foxo1JnkGtROSA26SorTgCAGcatlacZ11MiyaTgPomc1cre16Lowl
• hypoglycemia_Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0000189I129S4SvJaeC57BL6DBA2FVBNPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaTgPomc1cre16LowlTgCAGcatlacZ11Miya