Marc H G P. Raaijmakers, et.al., Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia., Nature, 2010, 464

http://rdf.ncbi.nlm.nih.gov/pubmed/20305640

Marc H G P. Raaijmakers, et.al., Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia., Nature, 2010, 464

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD22038
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD22038

allele

http://purl.org/net/cito/citesAsAuthority

• Sbds<tm1Dats>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4452398

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal megakaryocyte differentiation_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000229I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal bone structure_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0003795IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• abnormal neutrophil morphology_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005065IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• impaired hematopoiesis_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0001606I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal myeloid leukocyte morphology_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008250IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• abnormal megakaryocyte morphology_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002417IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• extramedullary hematopoiesis_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000240I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal bone marrow morphology_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002397IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• decreased B cell number_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005017IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• abnormal megakaryocyte morphology_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002417I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• increased facial tumor incidence_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008018I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal myeloid leukocyte morphology_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008250I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• impaired hematopoiesis_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0001606IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• decreased leukocyte cell number_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000221IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• decreased leukocyte cell number_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000221I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• increased compact bone volume_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(BGLAP-cre)1Clem/0
  http://metadb.riken.jp/0010964I129C57BL6FVBNDicer1tm1MmkDicer1tm1MmkTgBGLAPcre1Clem0Dicer1tm1MmkTgBGLAPcre1Clem
• decreased B cell number_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005017I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal bone structure_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0003795I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• increased bone marrow cell number_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000321I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal skeleton development_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002113I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• giant platelets_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0030025I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal bone structure_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(BGLAP-cre)1Clem/0
  http://metadb.riken.jp/0003795I129C57BL6FVBNDicer1tm1MmkDicer1tm1MmkTgBGLAPcre1Clem0Dicer1tm1MmkTgBGLAPcre1Clem
• abnormal cardiovascular system morphology_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002127IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• thrombocytopenia_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0003179I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• premature death_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002083I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal neutrophil morphology_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005065I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• increased leukemia incidence_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002026I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• anemia_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0001577I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• enlarged spleen_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000691I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• decreased osteoblast cell number_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004989I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• increased myeloid sarcoma incidence_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0009439I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal bone marrow morphology_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002397I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• postnatal growth retardation_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0001732I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal cardiovascular system morphology_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002127I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• abnormal granulocyte differentiation_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008111I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc
• decreased lymphocyte cell number_Sbds<tm1Dats>/Sbds<tm1Dats>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005016IC57BL6CD1Sbdstm1DatsSbdstm1DatsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSbdstm1Dats
• increased hemolymphoid system tumor incidence_Dicer1<tm1Mmk>/Dicer1<tm1Mmk>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010296I129C57BL6CD1Dicer1tm1MmkDicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc0Dicer1tm1MmkTgSp7tTAtetOEGFPcre1Amc