Javid. Moslehi, et.al., Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy., Circulation, 2010, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/20733101

Javid. Moslehi, et.al., Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy., Circulation, 2010, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00520
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00520

allele

http://purl.org/net/cito/citesAsAuthority

• Egln3<tm1Vlcg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5304712

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased angiogenesis_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005601I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• premature death_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002083I129S4SvJaeFVBNVhltm1JaeVhltm1JaeTgMyh6cre2182Mds0TgMyh6cre2182MdsVhltm1Jae
• decreased mitochondria number_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011629I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• decreased mitochondria number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011629I129S4SvJaeFVBNVhltm1JaeVhltm1JaeTgMyh6cre2182Mds0TgMyh6cre2182MdsVhltm1Jae
• increased angiogenesis_Gt(ROSA)26Sor<tm4(HIF2A*)Kael>/Gt(ROSA)26Sor<+>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005601I129S6SvEvTacFVBNGtROSA26Sortm4HIF2AKaelGtROSA26SorTgMyh6cre2182Mds0GtROSA26SorGtROSA26Sortm4HIF2AKaelTgMyh6cre2182Mds
• premature death_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002083I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• increased heart weight_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002833I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• cardiomyopathy_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005330I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• increased angiogenesis_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005601I129S4SvJaeFVBNVhltm1JaeVhltm1JaeTgMyh6cre2182Mds0TgMyh6cre2182MdsVhltm1Jae
• decreased ventricle muscle contractility_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005598I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• cardiomyopathy_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005330I129S4SvJaeFVBNVhltm1JaeVhltm1JaeTgMyh6cre2182Mds0TgMyh6cre2182MdsVhltm1Jae
• enlarged myocardial fiber_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004564I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• abnormal heart left ventricle morphology_Gt(ROSA)26Sor<tm4(HIF2A*)Kael>/Gt(ROSA)26Sor<+>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003921I129S6SvEvTacFVBNGtROSA26Sortm4HIF2AKaelGtROSA26SorTgMyh6cre2182Mds0GtROSA26SorGtROSA26Sortm4HIF2AKaelTgMyh6cre2182Mds
• abnormal heart left ventricle morphology_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003921I129S4SvJaeFVBNVhltm1JaeVhltm1JaeTgMyh6cre2182Mds0TgMyh6cre2182MdsVhltm1Jae
• cardiac interstitial fibrosis_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005608I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• myocardial fiber degeneration_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004566I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• decreased ventricle muscle contractility_Gt(ROSA)26Sor<tm4(HIF2A*)Kael>/Gt(ROSA)26Sor<+>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005598I129S6SvEvTacFVBNGtROSA26Sortm4HIF2AKaelGtROSA26SorTgMyh6cre2182Mds0GtROSA26SorGtROSA26Sortm4HIF2AKaelTgMyh6cre2182Mds
• decreased ventricle muscle contractility_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005598I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• cardiac fibrosis_Gt(ROSA)26Sor<tm4(HIF2A*)Kael>/Gt(ROSA)26Sor<+>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003141I129S6SvEvTacFVBNGtROSA26Sortm4HIF2AKaelGtROSA26SorTgMyh6cre2182Mds0GtROSA26SorGtROSA26Sortm4HIF2AKaelTgMyh6cre2182Mds
• myocardial fiber degeneration_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004566I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• increased response of heart to induced stress_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004485I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• enlarged heart_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000274I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• increased angiogenesis_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005601I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• liver vascular congestion_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010019I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• decreased mitochondria number_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011629I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• abnormal heart left ventricle morphology_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003921I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• increased heart weight_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002833I129S4SvJaeFVBNVhltm1JaeVhltm1JaeTgMyh6cre2182Mds0TgMyh6cre2182MdsVhltm1Jae
• abnormal heart left ventricle morphology_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003921I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• increased heart weight_Egln1<tm1Kael>/Egln1<tm1Kael>,Egln3<tm1Vlcg>/Egln3<tm1Vlcg>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002833I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelEgln3tm1VlcgEgln3tm1VlcgTgMyh6cre2182Mds0TgMyh6cre2182MdsEgln3tm1VlcgEgln1tm1Kael
• pulmonary vascular congestion_Egln1<tm1Kael>/Egln1<tm1Kael>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010018I129S6SvEvTacFVBNEgln1tm1KaelEgln1tm1KaelTgMyh6cre2182Mds0Egln1tm1KaelTgMyh6cre2182Mds
• decreased ventricle muscle contractility_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005598I129S4SvJaeFVBNVhltm1JaeVhltm1JaeTgMyh6cre2182Mds0TgMyh6cre2182MdsVhltm1Jae