Matthieu. Lacroix, et.al., Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/21088222

Matthieu. Lacroix, et.al., Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD40644
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40644
• CD02750
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02750

allele

http://purl.org/net/cito/citesAsAuthority

• E4f1<tm1.1Llca>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4867860

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• absent epidermis stratum granulosum_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0009560I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• abnormal keratinocyte physiology_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0003453I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• hyperkeratosis_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001242I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• abnormal keratinocyte physiology_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0003453I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• epidermal hyperplasia_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001222I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• epidermal hyperplasia_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001222I129Sv129S4SvJaeC57BL6SJLCdkn2atm1RdpCdkn2atm1RdpE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aE4f1tm11LlcaCdkn2atm1RdpPolr2aE4f1tm1PiscPolr2atm1creERT2Bbd
• hyperkeratosis_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001242I129Sv129S4SvJaeC57BL6SJLCdkn2atm1RdpCdkn2atm1RdpE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aE4f1tm11LlcaCdkn2atm1RdpPolr2aE4f1tm1PiscPolr2atm1creERT2Bbd
• abnormal keratinocyte physiology_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0003453I129Sv129S4SvJaeC57BL6SJLCdkn2atm1RdpCdkn2atm1RdpE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aE4f1tm11LlcaCdkn2atm1RdpPolr2aE4f1tm1PiscPolr2atm1creERT2Bbd
• absent suprabasal layer_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001234I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• spontaneous skin ulceration_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001209I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• abnormal skin morphology_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0002060I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• alopecia_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0000414I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• abnormal skin condition_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001191I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• abnormal hair follicle bulge morphology_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0009759I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• absent epidermis stratum granulosum_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0009560I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• hyperkeratosis_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001242I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• absent hair follicles_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0000378I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• abnormal epidermal layer morphology_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001216I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• dehydration_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001429I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• thick skin_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001200I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• abnormal skin physiology_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0005501I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• impaired wound healing_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001792I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• epidermal hyperplasia_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<+>
  http://metadb.riken.jp/0001222I129S4SvJaeC57BL6SJLE4f1tm1PiscE4f1tm11LlcaPolr2atm1creERT2BbdPolr2aPolr2aE4f1tm11LlcaPolr2atm1creERT2BbdE4f1tm1Pisc
• absent suprabasal layer_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0001234I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• postnatal lethality, complete penetrance_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0011085I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc
• abnormal skin physiology_E4f1<tm1Pisc>/E4f1<tm1.1Llca>,Tg(KRT5-cre)5132Jlj/0
  http://metadb.riken.jp/0005501I129S4SvJaeC57BL6DBA2JE4f1tm1PiscE4f1tm11LlcaTgKRT5cre5132Jlj0TgKRT5cre5132JljE4f1tm11LlcaE4f1tm1Pisc